PGS Publication: PGP000411

Publication Information (EuropePMC)
Title A Polygenic Score for Reduced Kidney Function and Adverse Outcomes in a Chronic Kidney Disease Cohort.
PubMed ID 36481179(Europe PMC)
doi 10.1016/j.kint.2022.11.013
Publication Date Dec. 5, 2022
Journal Kidney Int
Author(s) Steinbrenner I, Yu Z, Jin J, Schultheiss UT, Kotsis F, Grams ME, Coresh J, Wuttke M, GCKD investigators, Kronenberg F, Eckardt KU, Chatterjee N, Sekula P, Köttgen A.
Released in PGS Catalog: Dec. 20, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
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Multi-ancestry (excluding European)
African
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003377
(eGFRldpred_PGS)
 PGP000411 |
Steinbrenner I et al. Kidney Int (2022)
 Estimated glomerular filtration rate glomerular filtration rate 1,496,254
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003377/ScoringFiles/PGS003377.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016234 PGS003377
(eGFRldpred_PGS)
 PSS010065|
European Ancestry|
4,924 individuals
 PGP000411 |
Steinbrenner I et al. Kidney Int (2022)
 Reported Trait: Death HR: 1.11 [1.03, 1.2] — — Age, sex, PC1, PC2, baseline eGFR, log(UACR), diabetes —
PPM016235 PGS003377
(eGFRldpred_PGS)
 PSS010065|
European Ancestry|
4,924 individuals
 PGP000411 |
Steinbrenner I et al. Kidney Int (2022)
 Reported Trait: 3P-MACE HR: 1.15 [1.06, 1.25] — — Age, sex, PC1, PC2, baseline eGFR, log(UACR), diabetes —
PPM016237 PGS003377
(eGFRldpred_PGS)
 PSS010065|
European Ancestry|
4,924 individuals
 PGP000411 |
Steinbrenner I et al. Kidney Int (2022)
 Reported Trait: Cerebral hemorrhage HR: 1.06 [0.72, 1.55] — — Age, sex, PC1, PC2, baseline eGFR, log(UACR), diabetes —
PPM016238 PGS003377
(eGFRldpred_PGS)
 PSS010065|
European Ancestry|
4,924 individuals
 PGP000411 |
Steinbrenner I et al. Kidney Int (2022)
 Reported Trait: Stroke HR: 1.1 [0.95, 1.28] — — Age, sex, PC1, PC2, baseline eGFR, log(UACR), diabetes —
PPM016233 PGS003377
(eGFRldpred_PGS)
 PSS010065|
European Ancestry|
4,924 individuals
 PGP000411 |
Steinbrenner I et al. Kidney Int (2022)
 Reported Trait: Kidney failure HR: 1.12 [1.02, 1.22] — — Age, sex, PC1, PC2, baseline eGFR, log(UACR), diabetes —
PPM016236 PGS003377
(eGFRldpred_PGS)
 PSS010065|
European Ancestry|
4,924 individuals
 PGP000411 |
Steinbrenner I et al. Kidney Int (2022)
 Reported Trait: Acute myocardial infarction HR: 1.16 [1.02, 1.32] — — Age, sex, PC1, PC2, baseline eGFR, log(UACR), diabetes —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010065 — — 4,924 individuals,
60.0 % Male samples
 Mean = 60.1 years European — GCKD —