PGS Publication: PGP000414

Publication Information (EuropePMC)
Title Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations.
PubMed ID 36694225(Europe PMC)
doi 10.1186/s13073-023-01156-9
Publication Date Jan. 24, 2023
Journal Genome Med
Author(s) Xin J, Du M, Gu D, Jiang K, Wang M, Jin M, Hu Y, Ben S, Chen S, Shao W, Li S, Chu H, Zhu L, Li C, Chen K, Ding K, Zhang Z, Shen H, Wang M.
Released in PGS Catalog: Feb. 8, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
East Asian
South Asian
Additional Asian Ancestries
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000414 |
Xin J et al. Genome Med (2023)
Colorectal cancer colorectal cancer 1,145,689

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016277 PGS003395
East Asian Ancestry|
2,179 individuals
PGP000414 |
Xin J et al. Genome Med (2023)
Reported Trait: Incident colorectal cancer OR: 1.73 [1.56, 1.91] AUROC: 0.646 sex, age and principal components
PPM016278 PGS003395
European Ancestry|
2,573 individuals
PGP000414 |
Xin J et al. Genome Med (2023)
Reported Trait: Incident colorectal cancer OR: 1.48 [1.36, 1.62] AUROC: 0.608 sex, age and principal components
PPM016279 PGS003395
European Ancestry|
355,543 individuals
PGP000414 |
Xin J et al. Genome Med (2023)
Reported Trait: Incident colorectal cancer HR: 1.42 [1.37, 1.48] AUROC: 0.597 sex, age, center and principal components

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 1,289 cases
  • , 1,284 controls
European CORSA
  • 727 cases
  • , 1,452 controls
East Asian
PSS010094 355,543 individuals European UKB