PGS Publication: PGP000425

Publication Information (EuropePMC)
Title Risk Factors Associated With First and Second Primary Melanomas in a High-Incidence Population.
PubMed ID 36416830(Europe PMC)
doi 10.1001/jamadermatol.2022.4975
Publication Date Jan. 1, 2023
Journal JAMA Dermatol
Author(s) Olsen CM, Pandeya N, Dusingize JC, Neale RE, MacGregor S, Law MH, Whiteman DC, QSkin Study.
Released in PGS Catalog: Feb. 8, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003412
(PRS28_melanoma)
 PGP000424 |
Olsen CM et al. Br J Dermatol (2019)
 Melanoma melanoma 28
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003412/ScoringFiles/PGS003412.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017061 PGS003412
(PRS28_melanoma)
 PSS010107|
European Ancestry|
38,845 individuals
 PGP000425 |
Olsen CM et al. JAMA Dermatol (2023)
|Ext.		 Reported Trait: Second primary melanoma — — Hazard ratio (HR, high vs low tertile): 3.28 [2.06, 5.23] — —
PPM017062 PGS003412
(PRS28_melanoma)
 PSS010107|
European Ancestry|
38,845 individuals
 PGP000425 |
Olsen CM et al. JAMA Dermatol (2023)
|Ext.		 Reported Trait: First primary melanoma — — Hazard ratio (HR, high vs low tertile): 2.06 [1.71, 2.49] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010107 — Median = 7.4 years 38,845 individuals,
46.0 % Male samples
 Mean = 56.1 years European — QSKIN —