| Publication Information (EuropePMC) | |
| Title | Association Between Genetic Risk, Adherence to Healthy Lifestyle Behavior, and Thyroid Cancer Risk. |
| PubMed ID | 36508215(Europe PMC) |
| doi | 10.1001/jamanetworkopen.2022.46311 |
| Publication Date | Dec. 1, 2022 |
| Journal | JAMA Netw Open |
| Author(s) | Feng X, Wang F, Yang W, Zheng Y, Liu C, Huang L, Li L, Cheng H, Cai H, Li X, Chen X, Yang X. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS003437 (PRS23_TC) |
PGP000439 | Feng X et al. JAMA Netw Open (2022) |
Thyroid cancer | thyroid carcinoma | 23 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003437/ScoringFiles/PGS003437.txt.gz |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000207 (TC10_Ohio) |
PGP000085 | Liyanarachchi S et al. Proc Natl Acad Sci U S A (2020) |
Thyroid cancer | thyroid carcinoma | 10 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000207/ScoringFiles/PGS000207.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM017146 | PGS000207 (TC10_Ohio) |
PSS010136| European Ancestry| 264,956 individuals |
PGP000439 | Feng X et al. JAMA Netw Open (2022) |Ext. |
Reported Trait: Thyroid cancer | HR: 1.74 [1.56, 1.94] | AUROC: 0.62 [0.59, 0.64] | — | age, sex, and genetic composition, townsend deprivation index at recruitment, qualifications and average total household income before tax | — |
| PPM017148 | PGS003437 (PRS23_TC) |
PSS010136| European Ancestry| 264,956 individuals |
PGP000439 | Feng X et al. JAMA Netw Open (2022) |
Reported Trait: Incident thyroid cancer x total moderate to vigorous physical activity interaction | HR: 0.74 [0.57, 0.97] | — | — | age, sex, and genetic composition, townsend deprivation index at recruitment, qualifications and average total household income before tax | — |
| PPM017149 | PGS003437 (PRS23_TC) |
PSS010136| European Ancestry| 264,956 individuals |
PGP000439 | Feng X et al. JAMA Netw Open (2022) |
Reported Trait: Incident thyroid cancer x smoke intake interaction | HR: 0.48 [0.32, 0.72] | — | — | age, sex, and genetic composition, townsend deprivation index at recruitment, qualifications and average total household income before tax | — |
| PPM017145 | PGS003437 (PRS23_TC) |
PSS010136| European Ancestry| 264,956 individuals |
PGP000439 | Feng X et al. JAMA Netw Open (2022) |
Reported Trait: Thyroid cancer | HR: 1.95 [1.68, 2.26] | AUROC: 0.64 [0.61, 66.0] | — | age, sex, and genetic composition, townsend deprivation index at recruitment, qualifications and average total household income before tax | — |
| PPM017147 | PGS003437 (PRS23_TC) |
PSS010136| European Ancestry| 264,956 individuals |
PGP000439 | Feng X et al. JAMA Netw Open (2022) |
Reported Trait: Incident thyroid cancer x healthy lifestyle interaction | HR: 0.52 [0.37, 0.73] | — | — | age, sex, and genetic composition, townsend deprivation index at recruitment, qualifications and average total household income before tax | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS010136 | — | — | [
|
— | European | — | UKB | — |