PGS Publication: PGP000460

Publication Information (EuropePMC)
Title Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer's Disease Aetiopathogenesis in Men.
PubMed ID 36674414(Europe PMC)
doi 10.3390/ijms24020898
Publication Date Jan. 4, 2023
Journal Int J Mol Sci
Author(s) García-González P, de Rojas I, Moreno-Grau S, Montrreal L, Puerta R, Alarcón-Martín E, Quintela I, Orellana A, Andrade V, Adami PVM, Heilmann-Heimbach S, Gomez-Garre P, Periñán MT, Alvarez I, Diez-Fairen M, Nuñez Llaves R, Olivé Roig C, Garcia-Ribas G, Menéndez-González M, Martínez C, Aguilar M, Buongiorno M, Franco-Macías E, Saez ME, Cano A, Bullido MJ, Real LM, Rodríguez-Rodríguez E, Royo JL, Álvarez V, Pastor P, Piñol-Ripoll G, Mir P, Lara MC, Padilla MM, Sánchez-Juan P, Carracedo A, Valero S, Hernandez I, Tàrraga L, Ramirez A, Boada M, Ruiz A.
Released in PGS Catalog: April 12, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003575
(mloy-PRS)
 PGP000460 |
García-González P et al. Int J Mol Sci (2023)
 Mosaic loss of chromosome Y mosaic loss of chromosome Y measurement 114
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003575/ScoringFiles/PGS003575.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018177 PGS003575
(mloy-PRS)
 PSS010945|
European Ancestry|
2,286 individuals
 PGP000460 |
García-González P et al. Int J Mol Sci (2023)
 Reported Trait: Mosaic loss of chromosome Y in male aged 65-85 OR: 1.8 (1.07) — — — —
PPM018178 PGS003575
(mloy-PRS)
 PSS010945|
European Ancestry|
2,286 individuals
 PGP000460 |
García-González P et al. Int J Mol Sci (2023)
 Reported Trait: MCI-to-dementia progression in males HR: 1.11 (0.06) — — APOE genotype, age, and cohort ascertainment —
PPM018179 PGS003575
(mloy-PRS)
 PSS010945|
European Ancestry|
2,286 individuals
 PGP000460 |
García-González P et al. Int J Mol Sci (2023)
 Reported Trait: MCI-to-AD progression in males HR: 1.23 (0.08) — — APOE genotype, age, and cohort ascertainment —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010945 — — 2,286 individuals — European — NR GR@ACE-DEGESCO