PGS Publication: PGP000481

Publication Information (EuropePMC)
Title Validation of a Polygenic Score for Beta-Blocker Survival Benefit in Patients With Heart Failure Using the United Kingdom Biobank.
PubMed ID 36866666(Europe PMC)
doi 10.1161/circgen.121.003835
Publication Date March 3, 2023
Journal Circ Genom Precis Med
Author(s) Lanfear DE, Luzum JA, She R, Li J, Sabbah HN, Zeld N, Liu B, Peterson E, Keoki Williams L.
Released in PGS Catalog: Aug. 4, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
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Additional Asian Ancestries
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000134 |
Lanfear DE et al. Circ Heart Fail (2020)
Beta-blocker survival benefit response to beta blocker 44

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018550 PGS000718
European Ancestry|
7,141 individuals
PGP000481 |
Lanfear DE et al. Circ Genom Precis Med (2023)
Reported Trait: Survival beta (PRPcategory*BB-exposure): 0.576

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011019 7,141 individuals,
66.0 % Male samples
European UKB