PGS Publication: PGP000506

Publication Information (EuropePMC)
Title Genetic and Clinical Factors Underlying a Self-Reported Family History of Heart Disease.
PubMed ID 37011137(Europe PMC)
doi 10.1093/eurjpc/zwad096
Publication Date April 3, 2023
Journal Eur J Prev Cardiol
Author(s) Jowell A, Bhattacharya R, Marnell C, Wong M, Haidermota S, Trinder M, Fahed AC, Peloso GM, Honigberg MC, Natarajan P.
Released in PGS Catalog: Oct. 17, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000252 |
Ye Y et al. Circ Genom Precis Med (2021)
Coronary artery disease coronary artery disease 2,994,055

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019106 PGS001355
European Ancestry|
166,714 individuals
PGP000506 |
Jowell A et al. Eur J Prev Cardiol (2023)
Reported Trait: Family history of heart disease OR: 1.17 [1.16, 1.19]

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 72,052 cases
  • , 94,662 controls
44.3 % Male samples
Mean = 56.2 years
Sd = 8.05 years