Publication Information (EuropePMC) | |
Title | Sex Differences in the Association of Genome-Wide Systolic Blood Pressure Polygenic Risk Score With Hypertension. |
PubMed ID | 37807951(Europe PMC) |
doi | 10.1161/circgen.123.004259 |
Publication Date | Oct. 9, 2023 |
Journal | Circ Genom Precis Med |
Author(s) | Shetty NS, Pampana A, Patel N, Li P, Yerabolu K, Gaonkar M, Arora G, Arora P. |
Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS003970 (HARE_META_SBP_PRS_MALE) |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Systolic blood pressure | systolic blood pressure | 1,115,602 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003970/ScoringFiles/PGS003970.txt.gz | |
PGS003971 (HARE_META_SBP_PRS_FEMALE) |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Systolic blood pressure | systolic blood pressure | 1,115,520 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003971/ScoringFiles/PGS003971.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM019124 | PGS003970 (HARE_META_SBP_PRS_MALE) |
PSS011192| Multi-ancestry (including European)| 84,990 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Systolic Blood Pressure | β: 1.95 (0.06) | — | R²: 0.09 | — | — |
PPM019125 | PGS003971 (HARE_META_SBP_PRS_FEMALE) |
PSS011191| Multi-ancestry (including European)| 127,679 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Systolic Blood Pressure | β: 2.47 (0.05) | — | R²: 0.18 | — | — |
PPM019126 | PGS003970 (HARE_META_SBP_PRS_MALE) |
PSS011192| Multi-ancestry (including European)| 84,990 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Hypertension | OR: 1.22 [1.2, 1.23] | — | R²: 0.05 | — | — |
PPM019127 | PGS003971 (HARE_META_SBP_PRS_FEMALE) |
PSS011191| Multi-ancestry (including European)| 127,679 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Hypertension | OR: 1.29 [1.27, 1.3] | — | R²: 0.11 | — | — |
PPM019128 | PGS003970 (HARE_META_SBP_PRS_MALE) |
PSS011192| Multi-ancestry (including European)| 84,990 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Hypertension | — | — | Odds ratio (OR, high vs low tertile): 1.61 [1.46, 1.77] | age, and the first 10 principal components of genetic ancestry | — |
PPM019129 | PGS003971 (HARE_META_SBP_PRS_FEMALE) |
PSS011191| Multi-ancestry (including European)| 127,679 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Hypertension | — | — | Odds ratio (OR, high vs low tertile): 1.81 [1.68, 1.95] | age, and the first 10 principal components of genetic ancestry | — |
PPM019130 | PGS003970 (HARE_META_SBP_PRS_MALE) |
PSS011196| Multi-ancestry (including European)| 33,632 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Hypertension | — | — | Odds ratio (OR, high vs low tertile): 1.47 [1.27, 1.71] | age, and the first 10 principal components of genetic ancestry | — |
PPM019131 | PGS003971 (HARE_META_SBP_PRS_FEMALE) |
PSS011195| Multi-ancestry (including European)| 60,049 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Hypertension | — | — | Odds ratio (OR, high vs low tertile): 1.71 [1.48, 1.98] | age, and the first 10 principal components of genetic ancestry | — |
PPM019132 | PGS003970 (HARE_META_SBP_PRS_MALE) |
PSS011194| Multi-ancestry (including European)| 51,358 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Hypertension | — | — | Odds ratio (OR, high vs low tertile): 1.61 [1.44, 1.8] | age, and the first 10 principal components of genetic ancestry | — |
PPM019133 | PGS003971 (HARE_META_SBP_PRS_FEMALE) |
PSS011193| Multi-ancestry (including European)| 67,630 individuals |
PGP000512 | Shetty NS et al. Circ Genom Precis Med (2023) |
Reported Trait: Hypertension | — | — | Odds ratio (OR, high vs low tertile): 1.65 [1.45, 1.84] | age, and the first 10 principal components of genetic ancestry | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011191 | — | — | 127,679 individuals, 0.0 % Male samples |
— | European, African unspecified, East Asian, South Asian, Greater Middle Eastern (Middle Eastern, North African or Persian), Hispanic or Latin American | — | AllofUs | — |
PSS011192 | — | — | 84,990 individuals, 100.0 % Male samples |
— | European, African unspecified, East Asian, South Asian, Greater Middle Eastern (Middle Eastern, North African or Persian), Hispanic or Latin American | — | AllofUs | — |
PSS011193 | — | — | 67,630 individuals, 0.0 % Male samples |
— | European, African unspecified, East Asian, South Asian, Greater Middle Eastern (Middle Eastern, North African or Persian), Hispanic or Latin American | — | AllofUs | — |
PSS011194 | — | — | 51,358 individuals, 100.0 % Male samples |
— | European, African unspecified, East Asian, South Asian, Greater Middle Eastern (Middle Eastern, North African or Persian), Hispanic or Latin American | — | AllofUs | — |
PSS011195 | — | — | 60,049 individuals, 0.0 % Male samples |
— | European, African unspecified, East Asian, South Asian, Greater Middle Eastern (Middle Eastern, North African or Persian), Hispanic or Latin American | — | AllofUs | — |
PSS011196 | — | — | 33,632 individuals, 100.0 % Male samples |
— | European, African unspecified, East Asian, South Asian, Greater Middle Eastern (Middle Eastern, North African or Persian), Hispanic or Latin American | — | AllofUs | — |