PGS Publication: PGP000563

Publication Information (EuropePMC)
Title Genetic Basis of Altered Platelet Counts and Gestational Thrombocytopenia in Pregnancy.
PubMed ID 38064665(Europe PMC)
doi 10.1182/blood.2023021925
Publication Date Dec. 8, 2023
Journal Blood
Author(s) Yang Z, Hu L, Zhen J, Gu Y, Liu Y, Huang S, Wei Y, Zheng H, Guo X, Chen GB, Yang Y, Xiong L, Wei F, Liu S.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS004582
(PRSice_T1)
PGP000563 |
Yang Z et al. Blood (2023)
Platelet count during the first trimester platelet count 407,667
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004582/ScoringFiles/PGS004582.txt.gz
PGS004584
(PRSice_T3)
PGP000563 |
Yang Z et al. Blood (2023)
Platelet count during the third trimester platelet count 5,597
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004584/ScoringFiles/PGS004584.txt.gz
PGS004583
(PRSice_T2)
PGP000563 |
Yang Z et al. Blood (2023)
Platelet count during the second trimester platelet count 104,759
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004583/ScoringFiles/PGS004583.txt.gz
PGS004585
(PRSice_GT)
PGP000563 |
Yang Z et al. Blood (2023)
Gestational thrombocytopenia Thrombocytopenia 475,029
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004585/ScoringFiles/PGS004585.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020700 PGS004585
(PRSice_GT)
PSS011368|
East Asian Ancestry|
936 individuals
PGP000563 |
Yang Z et al. Blood (2023)
Reported Trait: Gestational Thrombocytopenia AUROC: 0.636 : 0.04
PPM020697 PGS004582
(PRSice_T1)
PSS011369|
East Asian Ancestry|
818 individuals
PGP000563 |
Yang Z et al. Blood (2023)
Reported Trait: Gestational Thrombocytopenia AUROC: 0.617 : 0.02
PPM020698 PGS004583
(PRSice_T2)
PSS011370|
East Asian Ancestry|
878 individuals
PGP000563 |
Yang Z et al. Blood (2023)
Reported Trait: Gestational Thrombocytopenia AUROC: 0.637 : 0.035
PPM020699 PGS004584
(PRSice_T3)
PSS011371|
East Asian Ancestry|
615 individuals
PGP000563 |
Yang Z et al. Blood (2023)
Reported Trait: Gestational Thrombocytopenia AUROC: 0.637 : 0.057

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011368 Pregnancy has at least one platelet count less than 150×109/L in the second or third trimester of pregnancy. Pregnancies complicated by preeclampsia, HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count), primary immune thrombocytopenia, HIV infection, hepatitis B virus, and hepatitis C virus infection or with one or more platelet count less than 50×109/L during pregnancy were excluded.
[
  • 97 cases
  • , 839 controls
]
,
0.0 % Male samples
East Asian
(Chinese)
NIPT PLUS 5,733 Chinese pregnant women underwent non-invasive prenatal PLUS testing.
PSS011369 Pregnancy with at least one platelet count measurements in each trimester during pregnancy. If multiple platelet count measurements were available, the earilest platelet count measurements within each trimester was chosen. 818 individuals,
0.0 % Male samples
East Asian
(Chinese)
NIPT PLUS 5,733 Chinese pregnant women underwent non-invasive prenatal PLUS testing.
PSS011370 Pregnancy with at least one platelet count measurements in each trimester during pregnancy. If multiple platelet count measurements were available, the earilest platelet count measurements within each trimester was chosen. 878 individuals,
0.0 % Male samples
East Asian
(Chinese)
NIPT PLUS 5,733 Chinese pregnant women underwent non-invasive prenatal PLUS testing.
PSS011371 Pregnancy with at least one platelet count measurements in each trimester during pregnancy. If multiple platelet count measurements were available, the earilest platelet count measurements within each trimester was chosen. 615 individuals,
0.0 % Male samples
East Asian
(Chinese)
NIPT PLUS 5,733 Chinese pregnant women underwent non-invasive prenatal PLUS testing.