PGS Publication: PGP000567

Publication Information (EuropePMC)
Title Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes.
PubMed ID 36520433(Europe PMC)
doi 10.1001/jamanetworkopen.2022.47162
Publication Date Dec. 1, 2022
Journal JAMA Netw Open
Author(s) Jung SH, Kim HR, Chun MY, Jang H, Cho M, Kim B, Kim S, Jeong JH, Yoon SJ, Park KW, Kim EJ, Yoon B, Jang JW, Kim Y, Hong JY, Choi SH, Noh Y, Kim KW, Kim SE, Lee JS, Jung NY, Lee J, Lee AY, Kim BC, Cho SH, Cho H, Kim JH, Jung YH, Lee DY, Lee JH, Lee ES, Kim SJ, Moon SY, Son SJ, Hong CH, Bae JS, Lee S, Na DL, Seo SW, Cruchaga C, Kim HJ, Won HH.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS004589
(PRS80_trans)
PGP000567 |
Jung SH et al. JAMA Netw Open (2022)
Alzheimer's disease Alzheimer disease 80
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004589/ScoringFiles/PGS004589.txt.gz
PGS004588
(PRS39_Eur)
PGP000567 |
Jung SH et al. JAMA Netw Open (2022)
Alzheimer's disease Alzheimer disease 39
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004588/ScoringFiles/PGS004588.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020711 PGS004588
(PRS39_Eur)
PSS011377|
East Asian Ancestry|
379 individuals
PGP000567 |
Jung SH et al. JAMA Netw Open (2022)
Reported Trait: Alzheimer's disease dementia OR: 1.85 [1.05, 3.32] Sex, age, education year, 4 PCs, APOE ε4 status
PPM020712 PGS004589
(PRS80_trans)
PSS011377|
East Asian Ancestry|
379 individuals
PGP000567 |
Jung SH et al. JAMA Netw Open (2022)
Reported Trait: Alzheimer's disease dementia OR: 2.09 [1.09, 4.04] Sex, age, education year, 4 PCs, APOE ε4 status

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011377
[
  • 159 cases
  • , 220 controls
]
,
39.3 % Male samples
Mean = 69.8 years
Sd = 9.3 years
East Asian
(Korean)
BICWALZS, PREMIER