PGS Publication: PGP000573

Publication Information (EuropePMC)
Title A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment.
PubMed ID 37272255(Europe PMC)
doi 10.1002/cac2.12448
Publication Date June 4, 2023
Journal Cancer Commun (Lond)
Author(s) Niedermaier T, Alwers E, Chen X, Heisser T, Hoffmeister M, Brenner H.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS002265
(PRS140_CRC)
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 140
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002265/ScoringFiles/PGS002265.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020729 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Colorectal cancer AUROC: 0.615 [0.529, 0.7]
PPM020730 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Advanced adenoma AUROC: 0.589 [0.562, 0.616]
PPM020731 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Non-advanced adenoma AUROC: 0.555 [0.534, 0.576]
PPM020732 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms AUROC: 0.591 [0.564, 0.617]
PPM020733 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (50 - 59 years) AUROC: 0.586 [0.544, 0.628]
PPM020734 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (60 - 79 years) AUROC: 0.597 [0.563, 0.631]
PPM020735 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (men) AUROC: 0.593 [0.558, 0.629]
PPM020736 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (women) AUROC: 0.593 [0.553, 0.633]
PPM020737 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (family history) AUROC: 0.555 [0.471 - 0.639
PPM020738 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (non family history) AUROC: 0.599 [0.57, 0.627]
PPM020739 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (previous colonoscopy) AUROC: 0.607 [0.551, 0.663]
PPM020740 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (no previous colonoscopy) AUROC: 0.585 [0.555, 0.616]

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011386 3,025 individuals Not reported BLITZ