Publication Information (EuropePMC) | |
Title | Joint impact of polygenic risk score and lifestyles on early- and late-onset cardiovascular diseases. |
PubMed ID | 38987358(Europe PMC) |
doi | 10.1038/s41562-024-01923-7 |
Publication Date | July 10, 2024 |
Journal | Nat Hum Behav |
Author(s) | China Kadoorie Biobank Collaborative Group. |
Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS004943 (ICH_MetaPRS) |
PGP000668 | China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024) |
Intracerebral hemorrhage | intracerebral hemorrhage | 2,124,631 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004943/ScoringFiles/PGS004943.txt.gz |
PGS004942 (IS_MetaPRS) |
PGP000668 | China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024) |
Ischemic stroke | Ischemic stroke | 4,765,243 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004942/ScoringFiles/PGS004942.txt.gz |
PGS004941 (CAD_MetaPRS) |
PGP000668 | China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024) |
Coronary artery disease | coronary artery disease | 3,711,629 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004941/ScoringFiles/PGS004941.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM021739 | PGS004941 (CAD_MetaPRS) |
PSS011772| East Asian Ancestry| 72,149 individuals |
PGP000668 | China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024) |
Reported Trait: Incident coronary artery disease | HR: 1.42 [1.36, 1.49] | C-index: 0.809 [0.799, 0.819] | — | age, sex | — |
PPM021740 | PGS004942 (IS_MetaPRS) |
PSS011774| East Asian Ancestry| 72,149 individuals |
PGP000668 | China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024) |
Reported Trait: Incident ischemic stroke | HR: 1.18 [1.16, 1.21] | C-index: 0.733 [0.727, 0.738] | — | age, sex | — |
PPM021741 | PGS004943 (ICH_MetaPRS) |
PSS011773| East Asian Ancestry| 72,149 individuals |
PGP000668 | China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024) |
Reported Trait: Incident intracerebral hemorrhage | HR: 1.31 [1.24, 1.39] | C-index: 0.748 [0.734, 0.761] | — | age, sex | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011773 | ICD10: I61 | Median = 12.2 years | 72,149 individuals, 40.2 % Male samples |
Mean = 51.7 years Sd = 10.5 years |
East Asian (Chinese) |
— | CKB | — |
PSS011774 | ICD10: I63 | Median = 12.2 years | 72,149 individuals, 40.2 % Male samples |
Mean = 51.7 years Sd = 10.5 years |
East Asian (Chinese) |
— | CKB | — |
PSS011772 | Including death resulting from ischemic heart disease [ICD10: I20-I25], nonfatal myocardial infarction [ICD10: I21-I23], and coronary revascularization | Median = 12.2 years | 72,149 individuals, 40.2 % Male samples |
Mean = 51.7 years Sd = 10.5 years |
East Asian (Chinese) |
— | CKB | — |