PGS Catalog - PGS000116 / Coronary Artery Disease (Polygenic Score)

Polygenic Score (PGS) ID: PGS000116

Predicted Trait
Reported Trait	Coronary Artery Disease
Mapped Trait(s)	coronary artery disease (EFO_0001645)

Released in PGS Catalog: March 27, 2020

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Terms and Licenses

CC0 1.0 Universal (CC0 1.0) Public Domain Dedication

Score Details

Score Construction
PGS Name	CAD_EJ2020
Development Method
Name	lassosum
Parameters	INFO score>0.999; N=1,037,385 variants; s=0.5; lambda=0.00428
Variants
Original Genome Build	GRCh37
Number of Variants	40,079
Effect Weight Type	NR

PGS Source
PGS Catalog Publication (PGP) ID	PGP000054
Citation (link to publication)	Elliott J et al. JAMA (2020)

Ancestry Distribution
Source of Variant Associations (GWAS)	European: 75.3% South Asian: 13.6% East Asian: 6% Hispanic or Latin American: 2.2% African: 1.7% Greater Middle Eastern: 1.2% 187,599 individuals (100%)
Score Development/Training	Multi-ancestry (including European): 100% European East Asian South Asian Additional Asian Ancestries Not Reported 80,103 individuals (100%)
PGS Evaluation	Multi-ancestry (including European): 83.3% European South Asian African East Asian Additional Asian Ancestries Not Reported European: 16.7% 12 Sample Sets

Development Samples

Source of Variant Associations (GWAS)

Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
GWAS Catalog: GCST003116 Europe PMC: 26343387	2,268 individuals	Greater Middle Eastern (Middle Eastern, North African or Persian)	40 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	3,139 individuals	African American or Afro-Caribbean	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	4,095 individuals	Hispanic or Latin American	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	11,323 individuals	East Asian	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	25,557 individuals	South Asian	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	141,217 individuals	European	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC

Score Development/Training

Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)	Phenotype Definitions & Methods	Age of Study Participants	Participant Follow-up Time	Additional Ancestry Description	Additional Sample/Cohort Information
—	80,103 individuals [ 15,947 cases , 64,156 controls ] , 68.24 % Male samples	European, East Asian, South Asian, Asian unspecified, NR	UKB	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 60.0 years	—	95% European, 0.2% Chinese, 1,4% Indian,0.4%Other Asian, 0.5% Pakistani, 1.1 % Other ancestries	Tuning (Case-Control) Set

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM000836	PSS000401\| Multi-ancestry (including European)\| 350,730 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease	—	C-index: 0.74 [0.73, 0.75]	—	QRISK3	—
PPM000837	PSS000389\| Multi-ancestry (including European)\| 203,620 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (over age 55)	—	C-index: 0.75 [0.74, 0.76]	—	QRISK3	—
PPM000838	PSS000385\| Multi-ancestry (including European)\| 147,110 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (under age 55)	—	C-index: 0.83 [0.81, 0.84]	—	QRISK3	—
PPM000839	PSS000393\| Multi-ancestry (including European)\| 146,573 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (in males)	—	C-index: 0.73 [0.72, 0.74]	—	QRISK3	—
PPM000840	PSS000397\| Multi-ancestry (including European)\| 204,157 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (in females)	—	C-index: 0.78 [0.76, 0.79]	—	QRISK3	—
PPM000807	PSS000399\| Multi-ancestry (including European)\| 352,660 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease	—	C-index: 0.76 [0.75, 0.76]	—	age,sex	—
PPM000808	PSS000399\| Multi-ancestry (including European)\| 352,660 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease	—	C-index: 0.78 [0.77, 0.79]	—	pooled cohort equations	—
PPM000810	PSS000387\| Multi-ancestry (including European)\| 204,675 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (over age 55)	—	C-index: 0.71 [0.7, 0.72]	—	age,sex	—
PPM000811	PSS000387\| Multi-ancestry (including European)\| 204,675 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (over age 55)	—	C-index: 0.74 [0.73, 0.74]	—	pooled cohort equations	—
PPM000813	PSS000383\| Multi-ancestry (including European)\| 147,985 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (under age 55)	—	C-index: 0.76 [0.75, 0.78]	—	age,sex	—
PPM000814	PSS000383\| Multi-ancestry (including European)\| 147,985 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (under age 55)	—	C-index: 0.8 [0.79, 0.82]	—	pooled cohort equations	—
PPM000816	PSS000391\| Multi-ancestry (including European)\| 147,363 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (in males)	—	C-index: 0.68 [0.67, 0.69]	—	age,sex	—
PPM000817	PSS000391\| Multi-ancestry (including European)\| 147,363 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (in males)	—	C-index: 0.71 [0.7, 0.72]	—	pooled cohort equations	—
PPM000819	PSS000395\| Multi-ancestry (including European)\| 205,297 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (in females)	—	C-index: 0.71 [0.7, 0.73]	—	age,sex	—
PPM000820	PSS000395\| Multi-ancestry (including European)\| 205,297 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (in females)	—	C-index: 0.76 [0.74, 0.77]	—	pooled cohort equations	—
PPM000806	PSS000399\| Multi-ancestry (including European)\| 352,660 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease	HR: 1.32 [1.3, 1.34]	C-index: 0.61 [0.6, 0.62]	—	—	—
PPM000809	PSS000387\| Multi-ancestry (including European)\| 204,675 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (over age 55)	—	C-index: 0.6 [0.59, 0.61]	—	—	—
PPM000812	PSS000383\| Multi-ancestry (including European)\| 147,985 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (under age 55)	—	C-index: 0.64 [0.63, 0.66]	—	—	—
PPM000815	PSS000391\| Multi-ancestry (including European)\| 147,363 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (in males)	—	C-index: 0.61 [0.6, 0.62]	—	—	—
PPM000818	PSS000395\| Multi-ancestry (including European)\| 205,297 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident coronary artery disease (in females)	—	C-index: 0.61 [0.6, 0.63]	—	—	—
PPM017098	PSS010122\| European Ancestry\| 4,218 individuals	PGP000433 \| de La Harpe R et al. Eur J Prev Cardiol (2023) \|Ext.	Reported Trait: Coronary heart disease (incident and prevalent)	OR: 1.69 [1.5, 1.92]	AUROC: 0.781 [0.575, 0.805]	—	sex, age	—
PPM017099	PSS010121\| European Ancestry\| 3,383 individuals	PGP000433 \| de La Harpe R et al. Eur J Prev Cardiol (2023) \|Ext.	Reported Trait: Incident coronary heart disease	HR: 1.67 [1.46, 1.92]	—	—	sex, age, 10 principal components	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS000383	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	147,985 individuals [ 1,350 cases , 146,635 controls ]	Range = [40.0, 55.0] years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS010121	Coronary artery disease (CAD), ccomprising either non-fatal myocardial infarction, death from coronary heart disease or symptomatic stable angina followed by a revascularization procedure, either by percutaneous coronary intervention (PCI), or by coronary artery bypass grafting (CABG) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036	Median = [10.7, 14.6] years	3,383 individuals [ 195 cases , 3,188 controls ] , 45.0 % Male samples	Mean = 52.3 years	European	—	CoLaus	right censored was death or latest evidence of good health, participant with statine therapy at baseline were excluded
PSS000385	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	147,110 individuals [ 1,339 cases , 145,771 controls ]	Range = [40.0, 55.0] years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS010122	Coronary artery disease (CAD), ccomprising either non-fatal myocardial infarction, death from coronary heart disease or symptomatic stable angina followed by a revascularization procedure, either by percutaneous coronary intervention (PCI), or by coronary artery bypass grafting (CABG) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036	Median = [10.6, 14.6] years	4,218 individuals [ 388 cases , 3,830 controls ] , 47.0 % Male samples	Mean = 53.4 years	European	—	CoLaus	right censored was death or latest evidence of good health
PSS000387	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	204,675 individuals [ 4,922 cases , 199,753 controls ]	Range = [55.0, 69.0] years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000389	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	203,620 individuals [ 4,900 cases , 198,720 controls ]	Range = [55.0, 69.0] years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000391	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	147,363 individuals [ 4,493 cases , 142,870 controls ] , 100.0 % Male samples	Mean = 55.79 years Sd = 8.35 years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000393	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	146,573 individuals [ 4,471 cases , 142,102 controls ] , 100.0 % Male samples	Mean = 55.8 years Sd = 8.3 years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000395	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	205,297 individuals [ 1,779 cases , 203,518 controls ] , 0.0 % Male samples	Mean = 56.0 years Sd = 8.01 years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000397	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	204,157 individuals [ 1,768 cases , 202,389 controls ] , 0.0 % Male samples	Mean = 56.0 years Sd = 8.0 years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000399	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	352,660 individuals [ 6,272 cases , 346,388 controls ] , 41.8 % Male samples	Mean = 55.9 years Range = [40.0, 69.0] years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000401	Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	350,730 individuals [ 6,239 cases , 344,491 controls ] , 41.0 % Male samples	Range = [40.0, 69.0] years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)