Polygenic Score (PGS) ID: PGS000123

Predicted Trait
Reported Trait Parkinson disease
Mapped Trait(s) Parkinson's disease (EFO_0002508)
Released in PGS Catalog: March 27, 2020
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name 2017_PD16
Variants
Original Genome Build NR
Number of Variants 16
Development Method
Name GWAS significant SNPs
Parameters The PRS was computed using the binary logarithm transformation of the reported ORs
PGS Source
PGS Catalog Publication (PGP) ID PGP000059
Citation (link to publication) Ibanez L et al. BMC Neurol (2017)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
108,990 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST002544
Europe PMC: 25064009
108,990 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000395 PSS000225|
European Ancestry|
469 individuals
PGP000059 |
Ibanez L et al. BMC Neurol (2017)
Reported Trait: Parkinson disease β: 5.84 [3.1, 8.59] Association (p-value): 3e-05 age at last assessment, sex, 2 PCs of ancestry
PPM000397 PSS000226|
European Ancestry|
786 individuals
PGP000059 |
Ibanez L et al. BMC Neurol (2017)
Reported Trait: Parkinson disease β: 4.85 [2.32, 7.39] Association (p-value): 0.00018 age at last assessment, sex, 2 PCs of ancestry
PPM000396 PSS000225|
European Ancestry|
469 individuals
PGP000059 |
Ibanez L et al. BMC Neurol (2017)
Reported Trait: Age at Onset (Survival) β: 16.62 [9.63, 23.61] Association (p-value): 3.19e-06 age at last assessment, sex, 2 PCs of ancestry Cox regression
PPM000398 PSS000226|
European Ancestry|
786 individuals
PGP000059 |
Ibanez L et al. BMC Neurol (2017)
Reported Trait: Age at Onset (Survival) β: 9.3 [3.59, 15.0] Association (p-value): 0.00141 age at last assessment, sex, 2 PCs of ancestry Cox regression

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000226
[
  • 493 cases
  • , 293 controls
]
,
58.27 % Male samples
European WUSTL Both the PPMI and WUSTL datasets are available by request from the PPMI website (www.ppmi-info.org)
PSS000225
[
  • 334 cases
  • , 135 controls
]
,
55.22 % Male samples
European PPMI Both the PPMI and WUSTL datasets are available by request from the PPMI website (www.ppmi-info.org)