Polygenic Score (PGS) ID: PGS000176

Predicted Trait
Reported Trait Mean corpuscular volume
Mapped Trait(s) mean corpuscular volume (EFO_0004526)
Additional Trait Information MCV
Released in PGS Catalog: April 29, 2020
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name mcv
Variants
Original Genome Build GRCh37
Number of Variants 685
Development Method
Name Genomewide-significant SNPs
Parameters Conditionally independent GWAS associations
PGS Source
PGS Catalog Publication (PGP) ID PGP000078
Citation (link to publication) Vuckovic D et al. Cell (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
408,112 individuals (100%)
PGS Evaluation
European: 66.7%
Greater Middle Eastern: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
408,112 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000553 PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean corpuscular volume : 0.1665 sex, age, 10 genetic PCs
PPM000532 PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean corpuscular volume : 0.15931 sex, age, 10 genetic PCs
PPM001774 PSS000911|
Greater Middle Eastern Ancestry|
13,989 individuals
PGP000147 |
Thareja G et al. Nat Commun (2021)
|Ext.
Reported Trait: Mean corpuscular volume Pearson correlation coefficent (r): 0.23

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000911 13,989 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)
QBB
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL