Polygenic Score (PGS) ID: PGS000201

Predicted Trait
Reported Trait Problematic Alcohol Use
Mapped Trait(s) alcohol dependence measurement (EFO_0007835)
Released in PGS Catalog: July 1, 2020
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Score Details

Score Construction
PGS Name PROB_ALC_COGA
Variants
Original Genome Build NR
Number of Variants 1,094,954
Development Method
Name PRS-CS
Parameters LD-reference panel = 1000G Europeans; SNPs selected to overlap HapMap3 and COGA
PGS Source
PGS Catalog Publication (PGP) ID PGP000084
Citation (link to publication) Barr PB et al. Transl Psychiatry (2020)
Ancestry Distribution
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

No sample information available.

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000626 PSS000339|
European Ancestry|
7,599 individuals
PGP000084 |
Barr PB et al. Transl Psychiatry (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.099 (0.01) ΔR-squared (vs. covariates alone): 0.01192 sex, age of last observation, 10 Genetic PCs, genotyping array, data collection site

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000339 7,599 individuals,
47.16 % Male samples
Mean = 36.94 years
Sd = 14.77 years
Range = [12.0, 91.0] years
European COGA