Polygenic Score (PGS) ID: PGS000202

Predicted Trait
Reported Trait Problematic alcohol use
Mapped Trait(s) alcohol dependence measurement (EFO_0007835)
Released in PGS Catalog: July 1, 2020
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Score Details

Score Construction
Development Method
Parameters LD-reference panel = 1000G Europeans; SNPs selected to overlap HapMap3 and FinnTwin12 Study
Original Genome Build NR
Number of Variants 1,083,002
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000084
Citation (link to publication) Barr PB et al. Transl Psychiatry (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
166,604 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 30482948
45,000 individuals European NR
GWAS Catalog: GCST006717
Europe PMC: 30336701
121,604 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000629 PSS000340|
European Ancestry|
1,251 individuals
PGP000084 |
Barr PB et al. Transl Psychiatry (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.043 (0.019) ΔR-squared (vs. covariates alone): 0.00456 sex, age of last observation, 10 Genetic PCs

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000340 1,251 individuals,
45.6 % Male samples
Mean = 21.9 years
Sd = 0.77 years
Range = [21.0, 26.0] years
FinnTwin12 Twin Study