Polygenic Score (PGS) ID: PGS000343

Predicted Trait
Reported Trait Psoriatic arthritis
Mapped Trait(s) psoriatic arthritis (EFO_0003778)
Released in PGS Catalog: Nov. 20, 2020
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Score Details

Score Construction
PGS Name wGRS_PsA_HLA
Development Method
Name HLA-specific significant variants.
Parameters SNPs within candidate risk genes shown to be associated with Psoriasis only (PsO) or Psoriatic Arthritis (PsA) in large cohorts.
Variants
Original Genome Build hg19
Number of Variants 5
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000111
Citation (link to publication) Smith MP et al. J Psoriasis Psoriatic Arthritis (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 100%
PGS Evaluation
Not Reported: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 25948071
 NR NR NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000972 PSS000490|
Ancestry Not Reported|
543 individuals
 PGP000111 |
Smith MP et al. J Psoriasis Psoriatic Arthritis (2020)
 Reported Trait: Psoriatic arthritis — AUROC: 0.569 [0.513, 0.625] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000490 Cases included physician-confirmed psoriatic arthritis (PsA). Controls inclded individuals with psoriasis with no history of joint symptoms (psoriasis only - PsO). —
[
  • 140 cases
  • , 403 controls
]
 — NR — NR —