Polygenic Score (PGS) ID: PGS000578

Predicted Trait
Reported Trait Cancer of prostate
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Additional Trait Information PheCode 185
Released in PGS Catalog: Dec. 15, 2020
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_UKB_20200608
Development Method
Name GWAS Hits
Parameters LD Clumping (MAF >= 1%, r^2 <= 0.1) & P<=5e-08
Variants
Original Genome Build GRCh37
Number of Variants 117
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000118
Citation (link to publication) Fritsche LG et al. Am J Hum Genet (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
644,688 individuals (100%)
Score Development/Training
European: 100%
32,122 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST000152
Europe PMC: 18264097
3,748 individuals European NR
GWAS Catalog: GCST000153
Europe PMC: 18264098
23,226 individuals European NR
GWAS Catalog: GCST000154
Europe PMC: 18264096
2,329 individuals European NR
GWAS Catalog: GCST000489
Europe PMC: 19767754
37,350 individuals European NR
GWAS Catalog: GCST001147
Europe PMC: 21743057
7,240 individuals European NR
GWAS Catalog: GCST001148
Europe PMC: 21743467
13,560 individuals European NR
GWAS Catalog: GCST001719
Europe PMC: 23104005
59,585 individuals European NR
GWAS Catalog: GCST001942
Europe PMC: 23535732
22,548 individuals European NR
GWAS Catalog: GCST002413
Europe PMC: 24740154
5,051 individuals European NR
GWAS Catalog: GCST002890
Europe PMC: 25939597
7,541 individuals European NR
GWAS Catalog: GCST003586
Europe PMC: 27262462
3,893 individuals European NR
GWAS Catalog: GCST006085
Europe PMC: 29892016
140,254 individuals European NR
GWAS Catalog: GCST000019
Europe PMC: 17401366
4,517 individuals European NR
GWAS Catalog: GCST000050
Europe PMC: 17603485
12,791 individuals European NR
GWAS Catalog: GCST000307
Europe PMC: 19117981
2,834 individuals European NR
GWAS Catalog: GCST000017
Europe PMC: 17401363
2,329 individuals European NR
GWAS Catalog: GCST007506
Europe PMC: 30410027
295,892 individuals European NR
Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PheCode:185; ICD9:185, 233.4; ICD10:C61, D07.5
[
  • 2,962 cases
  • , 29,160 controls
]
European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001263 PSS000573|
European Ancestry|
32,664 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Cancer of prostate OR: 1.746 [1.681, 1.813]
β: 0.557 (0.0192)
AUROC: 0.653 [0.642, 0.662] Nagelkerke's Pseudo-R²: 0.0565
Brier score: 0.0813
Odds Ratio (OR, top 1% vs. Rest): 4.31 [3.48, 5.33]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE185_GWAS-Catalog-r2019-05-03-X185_P_5e-08_UKB_20200608

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000573 PheCode:185; ICD9:185, 233.4; ICD10:C61, D07.5
[
  • 3,012 cases
  • , 29,652 controls
]
European UKB