Polygenic Score (PGS) ID: PGS000634

Predicted Trait
Reported Trait Thyroid cancer
Mapped Trait(s) thyroid carcinoma (EFO_0002892)
Additional Trait Information PheCode 193
Released in PGS Catalog: Dec. 15, 2020
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Score Details

Score Construction
Development Method
Parameters Parameters = auto; LD reference (eur)
Original Genome Build GRCh37
Number of Variants 1,119,238
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000118
Citation (link to publication) Fritsche LG et al. Am J Hum Genet (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
407,757 individuals (100%)
Score Development/Training
European: 100%
4,481 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 32424355
  • 358 cases
  • , 407,399 controls
European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
Europe PMC: 32991828
  • 409 cases
  • , 4,072 controls
European MGI PheCode:193; ICD9CM:193, V10.87; ICD10CM:C73

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001319 PSS000558|
European Ancestry|
4,270 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Thyroid cancer OR: 1.119 [1.008, 1.241]
β: 0.112 (0.053)
AUROC: 0.535 [0.504, 0.567] Nagelkerke's Pseudo-R²: 0.00228
Brier score: 0.0827
Odds Ratio (OR, top 1% vs. Rest): 1.39 [0.562, 3.45]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE193_UKBB-SAIGE-HRC-X193_PRS-CS_MGI_20200608

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000558 PheCode:193; ICD9CM:193, V10.87; ICD10CM:C73
  • 389 cases
  • , 3,881 controls
European MGI