Polygenic Score (PGS) ID: PGS000669

Predicted Trait
Reported Trait Albumin [g/L]
Mapped Trait(s) serum albumin measurement (EFO_0004535)
Released in PGS Catalog: Feb. 3, 2021
Download Score FTP directory
Terms and Licenses
Creative Commons Attribution 4.0 International (CC BY 4.0)

Score Details

Score Construction
PGS Name snpnet.Albumin
Development Method
Name snpnet
Parameters 1,080,968 variants as input (directly genotyped variants, imputed HLA allelotypes, and CNVs)
Variants
Original Genome Build hg19
Number of Variants 11,912
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000128
Citation (link to publication) Sinnott-Armstrong N et al. Nat Genet (2021)
Ancestry Distribution
Score Development/Training
European: 100%
255,256 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
10 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
223,327 individuals European
(British)		 UKB — — — — Training
31,929 individuals European
(British)		 UKB — — — — Validation

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001397 PSS000627|
African Ancestry|
5,573 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.10081
Spearman's ρ: 0.121		 Age, sex, PCs(1-40) —
PPM001432 PSS000628|
East Asian Ancestry|
984 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.08916
Spearman's ρ: 0.198		 Age, sex, PCs(1-40) —
PPM001467 PSS000629|
European Ancestry|
21,516 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.13257
Spearman's ρ: 0.25		 Age, sex, PCs(1-40) —
PPM001502 PSS000630|
South Asian Ancestry|
6,687 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.15158
Spearman's ρ: 0.216		 Age, sex, PCs(1-40) —
PPM001537 PSS000631|
European Ancestry|
58,196 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.13054
Spearman's ρ: 0.262		 Age, sex, PCs(1-40) —
PPM007271 PSS007067|
East Asian Ancestry|
1,472 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.02049 [0.0072, 0.03378]
Incremental R2 (full-covars): 0.00193
PGS R2 (no covariates): 0.05108 [0.03075, 0.0714]		 age, sex, UKB array type, Genotype PCs —
PPM007274 PSS007070|
European Ancestry|
59,097 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.03793 [0.0351, 0.04076]
Incremental R2 (full-covars): 0.00267
PGS R2 (no covariates): 0.06779 [0.06413, 0.07145]		 age, sex, UKB array type, Genotype PCs —
PPM007270 PSS007066|
African Ancestry|
5,658 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.07255 [0.06041, 0.08469]
Incremental R2 (full-covars): 0.00087
PGS R2 (no covariates): 0.01339 [0.00784, 0.01894]		 age, sex, UKB array type, Genotype PCs —
PPM007272 PSS007068|
European Ancestry|
21,759 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.04362 [0.03866, 0.04859]
Incremental R2 (full-covars): 0.00252
PGS R2 (no covariates): 0.0618 [0.05601, 0.06759]		 age, sex, UKB array type, Genotype PCs —
PPM007273 PSS007069|
South Asian Ancestry|
6,786 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.0904 [0.07829, 0.10251]
Incremental R2 (full-covars): 0.00198
PGS R2 (no covariates): 0.04739 [0.03821, 0.05657]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007068 — — 21,759 individuals — European non-white British ancestry UKB —
PSS007069 — — 6,786 individuals — South Asian — UKB —
PSS007070 — — 59,097 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS000627 — — 5,573 individuals — African unspecified — UKB —
PSS000628 — — 984 individuals — East Asian — UKB —
PSS000629 — — 21,516 individuals — European Non-British White UKB —
PSS000630 — — 6,687 individuals — South Asian — UKB —
PSS000631 — — 58,196 individuals — European
(British)		 — UKB —
PSS007066 — — 5,658 individuals — African unspecified — UKB —
PSS007067 — — 1,472 individuals — East Asian — UKB —