Polygenic Score (PGS) ID: PGS000695

Predicted Trait
Reported Trait Sodium in urine [mmol/L]
Mapped Trait(s)
Released in PGS Catalog: Feb. 3, 2021
Download Score FTP directory
Terms and Licenses
Creative Commons Attribution 4.0 International (CC BY 4.0)

Score Details

Score Construction
PGS Name snpnet.Sodium_in_urine
Variants
Original Genome Build hg19
Number of Variants 5,833
Development Method
Name snpnet
Parameters 1,080,968 variants as input (directly genotyped variants, imputed HLA allelotypes, and CNVs)
PGS Source
PGS Catalog Publication (PGP) ID PGP000128
Citation (link to publication) Sinnott-Armstrong N et al. Nat Genet (2021)
Ancestry Distribution
Score Development/Training
European: 100%
255,256 individuals (100%)
PGS Evaluation
European: 50%
African: 16.7%
East Asian: 16.7%
South Asian: 16.7%
6 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
223,327 individuals European
(British)
UKB Training
31,929 individuals European
(British)
UKB Validation

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001588 PSS000836|
European Ancestry|
2,117 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Sodium in urine [mmol/L] Spearman's ρ: 0.059 Age, sex
PPM001563 PSS000753|
European Ancestry|
62,011 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Sodium in urine [mmol/L] : 0.09883
Spearman's ρ: 0.09
Age, sex, PCs(1-40)
PPM001528 PSS000752|
South Asian Ancestry|
6,993 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Sodium in urine [mmol/L] : 0.06605
Spearman's ρ: 0.059
Age, sex, PCs(1-40)
PPM001493 PSS000751|
European Ancestry|
22,812 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Sodium in urine [mmol/L] : 0.11027
Spearman's ρ: 0.077
Age, sex, PCs(1-40)
PPM001458 PSS000750|
East Asian Ancestry|
1,044 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Sodium in urine [mmol/L] : 0.09743
Spearman's ρ: 0.068
Age, sex, PCs(1-40)
PPM001423 PSS000749|
African Ancestry|
5,781 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Sodium in urine [mmol/L] : 0.0456
Spearman's ρ: 0.029
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000749 5,781 individuals African unspecified UKB
PSS000750 1,044 individuals East Asian UKB
PSS000751 22,812 individuals European Non-British White UKB
PSS000752 6,993 individuals South Asian UKB
PSS000753 62,011 individuals European
(British)
UKB
PSS000836 2,117 individuals European Participants self-identifying as white MESA