Polygenic Score (PGS) ID: PGS000714

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: Feb. 3, 2021
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Score Details

Score Construction
PGS Name PRS55_PC
Development Method
Name Genome-wide significant variants
Parameters p<5e-8, ORs <1.1 or >0.9
Variants
Original Genome Build NR
Number of Variants 55
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000130
Citation (link to publication) Sipeky C et al. Sci Rep (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
22,548 individuals (100%)
PGS Evaluation
European: 100%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST001942
Europe PMC: 23535732
 22,548 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001624 PSS000840|
European Ancestry|
5,138 individuals
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Reported Trait: Prostate cancer OR: 2.13 [1.9, 2.39] AUROC: 0.618 [0.6, 0.63] — — —
PPM001625 PSS000841|
European Ancestry|
4,683 individuals
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Reported Trait: Prostate cancer (clinical cases) OR: 2.18 [1.93, 2.45] AUROC: 0.622 [0.61, 0.64] — — —
PPM001626 PSS000843|
European Ancestry|
2,855 individuals
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Reported Trait: Prostate cancer (screening trial detected) OR: 1.92 [1.56, 2.37] AUROC: 0.597 [0.57, 0.63] — — —
PPM001627 PSS000842|
European Ancestry|
2,591 individuals
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Reported Trait: Metastatic prostate cancer OR: 1.47 AUROC: 0.549 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000840 Cases: clinically diagnosed or screen-detected prostate cancer. Controls: free of cancer —
[
  • 2,738 cases
  • , 2,400 controls
]
,
100.0 % Male samples
 — European
(Finnish)		 — FinRSPC, PHD —
PSS000841 Cases: clinically diagnosed with prostate cancer. Controls: free of cancer. —
[
  • 2,283 cases
  • , 2,400 controls
]
,
100.0 % Male samples
 — European
(Finnish)		 — FinRSPC, PHD —
PSS000842 — —
[
  • 191 cases
  • , 2,400 controls
]
,
100.0 % Male samples
 — European
(Finnish)		 — FinRSPC, PHD —
PSS000843 Cases: screen-detected prostate cancer. Controls: free of cancer. —
[
  • 455 cases
  • , 2,400 controls
]
,
100.0 % Male samples
 — European
(Finnish)		 — FinRSPC —