Polygenic Score (PGS) ID: PGS000752

Predicted Trait
Reported Trait Lipoprotein A concentration [nmol/L]
Mapped Trait(s) lipoprotein A measurement (EFO_0006925)
Released in PGS Catalog: March 22, 2021
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Score Details

Score Construction
PGS Name PGS_Lpa
Development Method
Name LDpred
Parameters ρ = 0.03, variants within 2 Mb of the LPA gene
Variants
Original Genome Build hg19
Number of Variants 11,446
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000157
Citation (link to publication) Dron JS et al. Circ Genom Precis Med (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
258,775 individuals (100%)
Score Development/Training
European: 100%
30,000 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 258,775 individuals European UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 20,000 individuals European UKB — — — — —
— 10,000 individuals European UKB — — — — Possible sample overlap between this dataset and the dataset used to evaluate the polygenic score.

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001911 PSS000954|
European Ancestry|
43,071 individuals
 PGP000157 |
Dron JS et al. Circ Genom Precis Med (2021)
 Reported Trait: Lipoprotein(a) concentration [nmol/L] — — Pearson correlation coefficient (r): 0.5 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000954 — — 43,071 individuals — European — UKB —