Polygenic Score (PGS) ID: PGS000755

Predicted Trait
Reported Trait Serum uric acid levels
Mapped Trait(s) uric acid measurement (EFO_0004761)
Released in PGS Catalog: April 7, 2021
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Score Details

Score Construction
PGS Name PRS_SUA
Development Method
Name Genome-wide significant variants
Parameters p < 5e-8, r^2 ≤ 0.2
Variants
Original Genome Build GRCh37
Number of Variants 14
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000161
Citation (link to publication) Cho SK et al. Sci Rep (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
6,881 individuals (100%)
PGS Evaluation
East Asian: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST010512
Europe PMC: 32514006
 6,881 individuals East Asian KoGES

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001923 PSS000964|
East Asian Ancestry|
1,167 individuals
 PGP000161 |
Cho SK et al. Sci Rep (2020)
 Reported Trait: Serum uric acid levels β: 0.237 (0.033) — — Sex, age, BMI, eGFR, diabetes, hypertension, hyperlipidaemia, systolic blood pressure, total cholesterol, HDL cholesterol, triglycerides Only 11 of the 14 SNPs were utilised within the polygenic score
PPM001924 PSS000965|
East Asian Ancestry|
2,027 individuals
 PGP000161 |
Cho SK et al. Sci Rep (2020)
 Reported Trait: Serum uric acid levels β: 0.211 (0.022) — — Sex, age, BMI, eGFR, diabetes, hypertension, hyperlipidaemia, systolic blood pressure, total cholesterol, HDL cholesterol, triglycerides Only 13 of the 14 SNPs were utilised within the polygenic score

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000964 — — 1,167 individuals,
40.19 % Male samples
 Mean = 64.61 years
Sd = 8.26 years		 East Asian
(Korean)		 — KoGES —
PSS000965 — — 2,027 individuals,
56.14 % Male samples
 Mean = 39.35 years
Sd = 8.87 years		 East Asian
(Korean)		 — NR —