Polygenic Score (PGS) ID: PGS000762

Predicted Trait
Reported Trait Hearing difficulty
Mapped Trait(s) age-related hearing impairment (EFO_0005782)
Released in PGS Catalog: April 28, 2021
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Score Details

Disclaimer: The original published polygenic score is unavailable. The authors have provided an alternative polygenic for the Catalog. Please note some details and performance metrics may differ from the publication.
Score Construction
Development Method
Name PRSice
Parameters INFO: 0.9, MAF: 0.01, clump-r2: 0.1, p≤ 0.48; software version = 2.1.3.beta
Original Genome Build hg19
Number of Variants 100,325
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000165
Citation (link to publication) Cherny SS et al. Eur J Hum Genet (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
250,389 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008899
Europe PMC: 31564434
250,389 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001938 PSS000972|
European Ancestry|
3,636 individuals
PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
Reported Trait: Hearing difficulties : 0.0911 Age, sex

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000972 Hearing difficulty cases were defined as responding either ‘Yes, diagnosed by doctor or health professional’ or ‘Yes, not diagnosed by health professional’ to ‘Do you suffer from hearing loss?’ while participants that responded ‘No’ were assigned as controls.
  • 970 cases
  • , 2,666 controls
8.5 % Male samples
Mean = 60.34 years
Sd = 10.18 years