Polygenic Score (PGS) ID: PGS000781

Predicted Trait
Reported Trait Glioma
Mapped Trait(s)
Released in PGS Catalog: May 28, 2021
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Score Details

Score Construction
PGS Name GRS7_Glio
Development Method
Name Genome-wide significant variants
Parameters NR
Original Genome Build NR
Number of Variants 5
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000185
Citation (link to publication) Adel Fahmideh M et al. Sci Rep (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
30,659 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004347
Europe PMC: 28346443
30,659 individuals European 14 cohorts
  • AGS
  • ,B58C
  • ,CGEMS
  • ,DoNBONN
  • ,GICC
  • ,GliomaScan
  • ,HNR
  • ,Interphone
  • ,KORA
  • ,MAYO
  • ,SdNM

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002036 PSS001009|
Multi-ancestry (including European)|
734 individuals
PGP000185 |
Adel Fahmideh M et al. Sci Rep (2019)
Reported Trait: Pediatric brain tumors OR: 1.25 [1.06, 1.49] : 0.012 Age, sex, country

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001009 Cases include participants with the following tumors: Astrocytomas (ICCC-3 group IIIb), Other gliomas (ICCC-3 group IIId), Ependymomas (ICCC-3 group IIIa), Intracranial embryonal tumors (ICCC-3 group IIIc), other specified intracranial neoplasms (ICCC-3 group IIIe), unspecified intracranial neoplasms (ICCC-3 group IIIf)
  • 245 cases
  • , 489 controls
54.09 % Male samples
European, NR European = 454, NR =280 CEFALO