Polygenic Score (PGS) ID: PGS000793

Predicted Trait
Reported Trait Ovarian cancer
Mapped Trait(s) ovarian carcinoma (EFO_0001075)
Released in PGS Catalog: May 28, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name CC_Ovary_IV
Development Method
Name 36 variants from Graff et al (PGS000082) with inverse variant weights
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 36
Effect Weight Type Inverse-variance weighting
PGS Source
PGS Catalog Publication (PGP) ID PGP000186
Citation (link to publication) Kachuri L et al. Nat Commun (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
152,183 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST001917
Europe PMC: 23544013
 2,727 individuals European CIMBA
GWAS Catalog: GCST002748
Europe PMC: 25581431
 13,491 individuals European 10 cohorts
  • B58C
  • ,FOTS
  • ,MOCS
  • ,NCOCS
  • ,RMH
  • ,SEARCH
  • ,TBOCS
  • ,UKCRC
  • ,UKFOCR
  • ,UKOPS
GWAS Catalog: GCST004462
Europe PMC: 28346442
 85,426 individuals European 95 cohorts
  • AOCS
  • ,BCFR-AU
  • ,BCFR-NY
  • ,BCFR-PA
  • ,BCFR-UTAH
  • ,BFBOCC
  • ,BMBSA
  • ,BOCC
  • ,BOCS
  • ,BRICOH
  • ,BioVU
  • ,CNIO
  • ,COH
  • ,CONSIT_TEAM
  • ,CopBCS
  • ,DEMOKRITOS
  • ,DFCI
  • ,DKFZ
  • ,DOVE
  • ,DPMS
  • ,EMBRACE
  • ,EPIC
  • ,FCCC
  • ,FOTS
  • ,FROC&GEOCS
  • ,G-FaST
  • ,GC-HBOC
  • ,GEMO
  • ,GOCS
  • ,Georgetown
  • ,HCSC
  • ,HEBCS
  • ,HEBON
  • ,HJOCS
  • ,HMOCS
  • ,HOCS
  • ,HOPE
  • ,HUNBOCS
  • ,HUOCS
  • ,HUVH
  • ,HeOCS
  • ,ICO
  • ,IHCC
  • ,INHERIT
  • ,IOVHBOCS
  • ,IPOBCS
  • ,KUMC
  • ,LAC-CCOC
  • ,LUHR
  • ,MALOVA
  • ,MAYO
  • ,MCGILL
  • ,MDACCS
  • ,MEC
  • ,MOCS
  • ,MOF
  • ,MSKCC
  • ,MUV
  • ,NC-BCFR
  • ,NCI
  • ,NCOCS
  • ,NECC
  • ,NHS
  • ,NJOCS
  • ,NNPIO
  • ,NOCS
  • ,NRG_ONCOLOGY
  • ,NSUHS
  • ,OCGN
  • ,OFBCR
  • ,OSUCCG
  • ,OUH
  • ,OVAL-BC
  • ,PLCO
  • ,POCS
  • ,SEARCH
  • ,SHMC
  • ,SWE
  • ,SWE-BRCA
  • ,Sisters
  • ,TBOCS
  • ,UBNS
  • ,UC
  • ,UCIOCS
  • ,UCSF
  • ,UDP
  • ,UKFOCR
  • ,UKGRFOCR
  • ,UPENN
  • ,UPITT
  • ,VFCTG
  • ,WCPSOCCI
  • ,WCRI
  • ,WOCS
  • ,kConFab
GWAS Catalog: GCST000802
Europe PMC: 20852632
 4,122 individuals European 6 cohorts
  • B58C
  • ,CoRGI
  • ,RMH-OCS
  • ,SEARCH-OCS
  • ,UKFOCR
  • ,UKOPS
GWAS Catalog: GCST001258
Europe PMC: 21964575
 42,247 individuals European 7 cohorts
  • ICR
  • ,LUHR
  • ,NBS
  • ,Nijmegen
  • ,ODZH
  • ,TAMPERE
  • ,deCODE
GWAS Catalog: GCST000455
Europe PMC: 19648919
 4,170 individuals European 6 cohorts
  • B58C
  • ,RMH
  • ,SEARCH
  • ,UKCRC
  • ,UKFOCR
  • ,UKOPS

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002064 PSS001021|
European Ancestry|
211,958 individuals
 PGP000186 |
Kachuri L et al. Nat Commun (2020)
 Reported Trait: Incident ovarian cancer HR: 1.2 [1.1, 1.32] AUROC: 0.66
C-index: 0.654 (0.015)		 R²: 0.193 Age at assessment, family history of breast cancer, genotyping array, PCs(1-15), parity ( ≥1 live birth vs. none), body mass index, Menopausal status (pre-menopausal vs. post-menopausal vs. unknown or hysterectomy), ever used hormone replacement therapy, oral contraceptive use (never used (0) vs. <20 years vs. ≥20 years), BMI*menopausal status C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001021 Individuals with at least one recorded incident diagnosis of a borderline, in situ, or malignant primary cancer were defined as cases. —
[
  • 445 cases
  • , 211,513 controls
]
,
0.0 % Male samples
 — European — UKB —