Polygenic Score (PGS) ID: PGS000798

Predicted Trait
Reported Trait Coronary heart disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: May 28, 2021
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Score Details

Score Construction
PGS Name 157SNP_GRS
Development Method
Name Genome-wide significant variants
Parameters R^2 > 0.6
Variants
Original Genome Build hg19
Number of Variants 157
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000187
Citation (link to publication) Severance LM et al. J Cardiovasc Comput Tomogr (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 100%
547,261 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • East Asian
  • African
  • Hispanic or Latin American
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005195
Europe PMC: 29212778
 547,261 individuals Not reported CARDIoGRAMplusC4D, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002075 PSS001026|
Multi-ancestry (including European)|
6,660 individuals
 PGP000187 |
Severance LM et al. J Cardiovasc Comput Tomogr (2019)
 Reported Trait: Cornary artery calcium (non-zero CAC score) OR: 1.37 [1.29, 1.45] — — Age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001026 — — 2,647 individuals — European — MESA —
PSS001026 — — 728 individuals — East Asian — MESA —
PSS001026 — — 1,834 individuals — African American or Afro-Caribbean — MESA —
PSS001026 — — 1,451 individuals — Hispanic or Latin American — MESA —