Polygenic Score (PGS) ID: PGS000800

Predicted Trait
Reported Trait Allergic disease
Mapped Trait(s) allergic disease (MONDO_0005271)
Released in PGS Catalog: June 11, 2021
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Score Details

Score Construction
PGS Name GRSw_SHARE
Development Method
Name Variants significantly associated with allergic diseases
Parameters P < 3e-8
Variants
Original Genome Build GRCh37
Number of Variants 133
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000189
Citation (link to publication) Dijk FN et al. J Allergy Clin Immunol (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
360,838 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005038
Europe PMC: 29083406
 360,838 individuals European 12 cohorts
  • 23andMe
  • ,AAGC
  • ,ALSPAC
  • ,CATSS
  • ,GENUFAD
  • ,GERA
  • ,LifeLines
  • ,NTR
  • ,SALTY
  • ,STR
  • ,TwinGene
  • ,UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002081 PSS001029|
European Ancestry|
1,858 individuals
 PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
 Reported Trait: Asthma ever, at age 8 years OR: 1.72 [1.21, 2.44] — — — —
PPM002083 PSS001028|
European Ancestry|
427 individuals
 PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
 Reported Trait: Asthma ever, at age 8 years OR: 4.75 — — — —
PPM002082 PSS001029|
European Ancestry|
1,858 individuals
 PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
 Reported Trait: Asthma ever, at age 8 years — AUROC: 0.65 — Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) —
PPM002084 PSS001028|
European Ancestry|
427 individuals
 PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
 Reported Trait: Asthma ever, at age 8 years — AUROC: 0.7 — Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001028 Cases were children with asthma ever, at age 8 years. Cases were defined using an adjusted diagnosis of asthma ever at age 8 years based on (1) 1 or more attacks of wheeze in the last 12 months or (2) inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had at least 1 of these characteristics was categorized as having asthma. —
[
  • 215 cases
  • , 212 controls
]
,
56.2 % Male samples
 — European
(Swedish)		 — BAMSE Possible sample overlap of up to 100% between this dataset and the datasets used to source variants for GRSw_TAGC.
PSS001029 Cases were children with asthma ever, at age 8 years, in which asthma was defined by the following characteristics: 1 or more attacks of wheeze in the last 12 months, 1 or more events of shortness of breath (dyspnea) in the last 12 months, or inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had 1 or more of these characteristics was categorized as having asthma. —
[
  • 792 cases
  • , 1,066 controls
]
,
51.1 % Male samples
 — European — PIAMA Possible sample overlap of up to 19% between this dataset and the datasets used to source variants for GRSw_TAGC.