Polygenic Score (PGS) ID: PGS000810

Predicted Trait
Reported Trait Allergic disease (asthma, hay fever or eczema)
Mapped Trait(s) allergic disease (MONDO_0005271)
Released in PGS Catalog: July 2, 2021
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Score Details

Score Construction
PGS Name wGRS136_Allergy
Development Method
Name Variants significantly associated with allergic disease (asthma, hay fever or eczema)
Parameters P < 3e-8
Variants
Original Genome Build GRCh37
Number of Variants 136
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000195
Citation (link to publication) Ferreira MA et al. Nat Genet (2017)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
360,838 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005038
Europe PMC: 29083406
 360,838 individuals European 12 cohorts
  • 23andMe
  • ,AAGC
  • ,ALSPAC
  • ,CATSS
  • ,GENUFAD
  • ,GERA
  • ,LifeLines
  • ,NTR
  • ,SALTY
  • ,STR
  • ,TwinGene
  • ,UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002160 PSS001055|
European Ancestry|
22,029 individuals
 PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.		 Reported Trait: Asthma age of onset — — Percent (%) of cases with asthma prior to age 16 (bottom 10% of GRS): 14.0 — —
PPM002161 PSS001055|
European Ancestry|
22,029 individuals
 PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.		 Reported Trait: Asthma age of onset — — Percent (%) of cases with asthma prior to age 16 (top 10% of GRS): 35.0 — —
PPM002162 PSS001055|
European Ancestry|
22,029 individuals
 PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.		 Reported Trait: Asthma age of onset — — Median age of asthma onset in years (bottom 10% of GRS): 42.0 — —
PPM002163 PSS001055|
European Ancestry|
22,029 individuals
 PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.		 Reported Trait: Asthma age of onset — — Median age of asthma onset in years (top 10% of GRS): 30.0 — —
PPM002164 PSS001057|
European Ancestry|
14,474 individuals
 PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.		 Reported Trait: Hay fever age of onset — — Median age of onset in years (bottom 10% of GRS): 25.0 — —
PPM002165 PSS001057|
European Ancestry|
14,474 individuals
 PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.		 Reported Trait: Hay fever age of onset — — Median age of onset in years (top 10% of GRS): 18.0 — —
PPM002166 PSS001056|
European Ancestry|
3,969 individuals
 PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.		 Reported Trait: Eczema age of onset — — Median age of onset in years (bottom 10% of GRS): 30.0 — —
PPM002167 PSS001056|
European Ancestry|
3,969 individuals
 PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.		 Reported Trait: Eczema age of onset — — Median age of onset in years (top 10% of GRS): 23.0 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001057 All individuals suffered from hay fever and no other allergic diseases. All individuals were identified from a questionnaire. To identify individuals who reported suffering specifically from hay fever, information reported in the verbal interview (field 20002) and ICD10 codes (fields 41202 and 41204) were considered, as described for asthma — 14,474 individuals,
49.0 % Male samples
 Mean = 55.1 years
Range = [40.0, 70.0] years		 European — UKB Possible sample overlap of up to 100% between this dataset and the dataset used to source wGRS136_Allergy.
PSS001055 All individuals suffered from asthma and no other allergic diseases. All individuals were identified from a questionnaire. Asthmatic individuals were those with (i) both a report of “Asthma” in field 6152 of questionnaire (self-reported medical conditions, specifically the question “Has a doctor ever told you that you have had any of the following conditions?”) and a code for asthma in field 20002 (verbal interview), or alternatively, an ICD10 code for asthma in fields 41202 (Diagnoses–main ICD10) or 41204 (Diagnoses–secondary ICD10); and (ii) no report of COPD in fields 6152 or 20002, nor of other respiratory diseases in field 20002. — 22,029 individuals,
45.0 % Male samples
 Mean = 56.6 years
Range = [38.0, 70.0] years		 European — UKB Possible sample overlap of up to 100% between this dataset and the dataset used to source wGRS136_Allergy.
PSS001056 All individuals suffered from eczema and no other allergic diseases. All individuals were identified from a questionnaire. The exact same approach (i.e. information from fields 20002, 41202 and 41204) was used to identify eczema cases. — 3,969 individuals,
43.0 % Male samples
 Mean = 55.4 years
Range = [40.0, 70.0] years		 European — UKB Possible sample overlap of up to 100% between this dataset and the dataset used to source wGRS136_Allergy.