Polygenic Score (PGS) ID: PGS000878

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: Aug. 26, 2021
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Score Details

Score Construction
PGS Name PRS4_PC
Development Method
Name Clumping of genome-wide significant SNPs
Parameters R^2 < 0.001
Variants
Original Genome Build NR
Number of Variants 4
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000224
Citation (link to publication) Oh JJ et al. Front Oncol (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
3,178 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 984 cases
  • , 2,194 controls
]
,
100.0 % Male samples
 East Asian
(Korean)		 KARE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002516 PSS001135|
East Asian Ancestry|
638 individuals
 PGP000224 |
Oh JJ et al. Front Oncol (2020)
 Reported Trait: Prostate cancer — AUROC: 0.637 Odds Ratio (OR, top 25% vs bottom 25%): 4.2 [2.32, 7.98] Age —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001135 Cases are individuals with prostate cancer. 80% of the cases are diagnosed with prostate cancer with a gleason score of ≥ 7. —
[
  • 514 cases
  • , 124 controls
]
,
100.0 % Male samples
 — East Asian
(Korean)		 — NR —