Polygenic Score (PGS) ID: PGS000908

Predicted Trait
Reported Trait Insomnia
Mapped Trait(s) insomnia (EFO_0004698)
Released in PGS Catalog: Oct. 7, 2021
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Score Details

Score Construction
PGS Name PRS_Insomnia
Development Method
Name SBayesR
Parameters --ldm ldm_ukb_50k_bigset_2.8M\ --pi 0.95,0.02,0.02,0.01 \ --gamma 0.0,0.01,0.1,1 \ --chain-length 25000 \ --burn-in 5000 \ --out-freq 10 \
Variants
Original Genome Build hg19
Number of Variants 2,746,982
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000238
Citation (link to publication) Campos AI et al. medRxiv (2021) Preprint
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,331,010 individuals (100%)
PGS Evaluation
European: 100%
10 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007988
Europe PMC: 30804565
1,331,010 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002950 PSS001293|
European Ancestry|
5,713 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Sertraline takers OR: 1.06 [0.99, 1.14] Variance explained (Nagelkerke's R2*100): 0.09 sex, age at study enrollment, genetic PCs 1-20
PPM002951 PSS001289|
European Ancestry|
4,362 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Escitalopram takers OR: 1.12 [1.03, 1.21] Variance explained (Nagelkerke's R2*100): 0.27 sex, age at study enrollment, genetic PCs 1-20
PPM002952 PSS001294|
European Ancestry|
3,964 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Venlafaxine takers OR: 1.03 [0.95, 1.11] Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20
PPM002953 PSS001285|
European Ancestry|
1,655 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Amitriptyline takers OR: 1.28 [1.07, 1.52] Variance explained (Nagelkerke's R2*100): 1.03 sex, age at study enrollment, genetic PCs 1-20
PPM002954 PSS001291|
European Ancestry|
1,986 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Mirtazapine takers OR: 1.03 [0.88, 1.2] Variance explained (Nagelkerke's R2*100): 0.01 sex, age at study enrollment, genetic PCs 1-20
PPM002955 PSS001287|
European Ancestry|
2,523 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Desvenlafaxine takers OR: 1.13 [1.03, 1.25] Variance explained (Nagelkerke's R2*100): 0.38 sex, age at study enrollment, genetic PCs 1-20
PPM002956 PSS001286|
European Ancestry|
2,585 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Citalopram takers OR: 1.08 [0.96, 1.21] Variance explained (Nagelkerke's R2*100): 0.12 sex, age at study enrollment, genetic PCs 1-20
PPM002957 PSS001290|
European Ancestry|
3,665 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Fluoxetine takers OR: 1.03 [0.94, 1.13] Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20
PPM002958 PSS001288|
European Ancestry|
1,994 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Duloxetine takers OR: 1.14 [1.02, 1.28] Variance explained (Nagelkerke's R2*100): 0.4 sex, age at study enrollment, genetic PCs 1-20
PPM002959 PSS001292|
European Ancestry|
1,577 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Paroxetine takers OR: 1.16 [1.01, 1.33] Variance explained (Nagelkerke's R2*100): 0.47 sex, age at study enrollment, genetic PCs 1-20

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001294
[
  • 793 cases
  • , 3,171 controls
]
European AGDS
PSS001285
[
  • 140 cases
  • , 1,515 controls
]
European AGDS
PSS001286
[
  • 367 cases
  • , 2,218 controls
]
European AGDS
PSS001287
[
  • 488 cases
  • , 2,035 controls
]
European AGDS
PSS001288
[
  • 382 cases
  • , 1,612 controls
]
European AGDS
PSS001289
[
  • 712 cases
  • , 3,650 controls
]
European AGDS
PSS001290
[
  • 582 cases
  • , 3,083 controls
]
European AGDS
PSS001291
[
  • 186 cases
  • , 1,800 controls
]
European AGDS
PSS001292
[
  • 235 cases
  • , 1,342 controls
]
European AGDS
PSS001293
[
  • 1,018 cases
  • , 4,695 controls
]
European AGDS