Polygenic Score (PGS) ID: PGS000909

Predicted Trait
Reported Trait Headache
Mapped Trait(s) Headache (HP_0002315)
Released in PGS Catalog: Oct. 7, 2021
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Score Details

Score Construction
PGS Name PRS_Headaches
Development Method
Name SBayesR
Parameters --ldm ldm_ukb_50k_bigset_2.8M\ --pi 0.95,0.02,0.02,0.01 \ --gamma 0.0,0.01,0.1,1 \ --chain-length 25000 \ --burn-in 5000 \ --out-freq 10 \
Variants
Original Genome Build hg19
Number of Variants 2,862,172
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000238
Citation (link to publication) Campos AI et al. medRxiv (2021) Preprint
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
441,088 individuals (100%)
PGS Evaluation
European: 100%
10 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
[
  • 39,283 cases
  • , 401,805 controls
]
European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002940 PSS001283|
European Ancestry|
5,719 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Sertraline takers OR: 1.16 [1.08, 1.25] Variance explained (Nagelkerke's R2*100): 0.49 sex, age at study enrollment, genetic PCs 1-20
PPM002941 PSS001279|
European Ancestry|
4,365 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Escitalopram takers OR: 1.06 [0.97, 1.16] Variance explained (Nagelkerke's R2*100): 0.08 sex, age at study enrollment, genetic PCs 1-20
PPM002942 PSS001284|
European Ancestry|
3,967 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Venlafaxine takers OR: 1.11 [1.01, 1.21] Variance explained (Nagelkerke's R2*100): 0.22 sex, age at study enrollment, genetic PCs 1-20
PPM002943 PSS001275|
European Ancestry|
1,657 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Amitriptyline takers OR: 1.09 [0.93, 1.28] Variance explained (Nagelkerke's R2*100): 0.15 sex, age at study enrollment, genetic PCs 1-20
PPM002944 PSS001281|
European Ancestry|
1,987 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Mirtazapine takers OR: 1.04 [0.9, 1.2] Variance explained (Nagelkerke's R2*100): 0.04 sex, age at study enrollment, genetic PCs 1-20
PPM002945 PSS001277|
European Ancestry|
2,524 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Desvenlafaxine takers OR: 1.08 [0.98, 1.2] Variance explained (Nagelkerke's R2*100): 0.16 sex, age at study enrollment, genetic PCs 1-20
PPM002946 PSS001276|
European Ancestry|
2,585 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Citalopram takers OR: 1.11 [0.98, 1.26] Variance explained (Nagelkerke's R2*100): 0.23 sex, age at study enrollment, genetic PCs 1-20
PPM002947 PSS001280|
European Ancestry|
3,670 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Fluoxetine takers OR: 1.02 [0.93, 1.12] Variance explained (Nagelkerke's R2*100): 0.01 sex, age at study enrollment, genetic PCs 1-20
PPM002948 PSS001278|
European Ancestry|
1,995 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Duloxetine takers OR: 1.03 [0.92, 1.15] Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20
PPM002949 PSS001282|
European Ancestry|
1,580 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Headaches in Paroxetine takers OR: 1.16 [1.0, 1.35] Variance explained (Nagelkerke's R2*100): 0.46 sex, age at study enrollment, genetic PCs 1-20

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001275
[
  • 140 cases
  • , 1,517 controls
]
European AGDS
PSS001276
[
  • 367 cases
  • , 2,218 controls
]
European AGDS
PSS001277
[
  • 489 cases
  • , 2,035 controls
]
European AGDS
PSS001278
[
  • 382 cases
  • , 1,613 controls
]
European AGDS
PSS001279
[
  • 712 cases
  • , 3,653 controls
]
European AGDS
PSS001280
[
  • 583 cases
  • , 3,087 controls
]
European AGDS
PSS001281
[
  • 186 cases
  • , 1,801 controls
]
European AGDS
PSS001282
[
  • 236 cases
  • , 1,344 controls
]
European AGDS
PSS001283
[
  • 1,020 cases
  • , 4,699 controls
]
European AGDS
PSS001284
[
  • 794 cases
  • , 3,173 controls
]
European AGDS