Polygenic Score (PGS) ID: PGS000912

Predicted Trait
Reported Trait Diastolic blood pressure
Mapped Trait(s) diastolic blood pressure (EFO_0006336)
Released in PGS Catalog: Oct. 7, 2021
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name ukb_dbp_prs
Development Method
Name PRS-CS
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,098,015
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000240
Citation (link to publication) Vaura F et al. Hypertension (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
361,194 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Neale Lab UKB GWAS (round 2)
 361,194 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002972 PSS001446|
European Ancestry|
218,754 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident hypertension HR: 1.41 [1.4, 1.42] — Hazard Ratio (HR, top 2.5% vs middle 60%): 2.26 [2.17, 2.36] Sex, collection year, genotyping batch, PCs(1-10) —
PPM002974 PSS001446|
European Ancestry|
218,754 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Late onset incident hypertension (≥55 years) HR: 1.26 [1.25, 1.28] — Hazard Ratio (HR, top 2.5% vs middle 60%): 1.6 [1.48, 1.73] Sex, collection year, genotyping batch, PCs(1-10) —
PPM002976 PSS001450|
European Ancestry|
9,906 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident hypertension — C-index: 0.803 — Age, sex, systolic blood pressure, diastolic blood pressure, body mass index, diabetes, current smoking —
PPM002973 PSS001446|
European Ancestry|
218,754 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Early onset incident hypertension (< 55 years) HR: 1.58 [1.56, 1.6] — Hazard Ratio (HR, top 2.5% vs middle 60%): 2.78 [2.64, 2.93] Sex, collection year, genotyping batch, PCs(1-10) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001446 Cases were individuals with incident hypertension. Hypertension was defined as persistently high systemic arterial blood pressure based on multiple blood pressure readings (consistent systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg) or medical expenses reimbursement history. Diagnoses were based on the International Classification of Diseases (ICD) 8 codes (I1[0-3]/I15/I674) , ICD-9 codes (I1[0-3]/I15/I674), and ICD-10 codes (I1[0-3]/I15/I674). Of the 55,917 cases, 27,361 had early-onset incident hypertension, whilst 28,556 had late-onset incident hypertension. Early-onset and late-onset hypertension were defined as age of onset <55 and ≥55 years, respectively. —
[
  • 55,917 cases
  • , 162,837 controls
]
 — European
(Finnish)		 — FinnGen —
PSS001450 Cases were individuals with incident hypertension. Hypertension was defined as persistently high systemic arterial blood pressure based on multiple blood pressure readings (consistent systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg) or medical expenses reimbursement history. Diagnoses were based on the International Classification of Diseases (ICD) 8 codes (I1[0-3]/I15/I674) , ICD-9 codes (I1[0-3]/I15/I674), and ICD-10 codes (I1[0-3]/I15/I674). —
[
  • 725 cases
  • , 9,181 controls
]
 — European
(Finnish)		 — FINRISK —