Polygenic Score (PGS) ID: PGS000914

Predicted Trait
Reported Trait Abnormal electrocardiogram
Mapped Trait(s) Abnormal EKG (HP_0003115)
Released in PGS Catalog: Oct. 7, 2021
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Score Details

Score Construction
Development Method
Name Candidate SNPs significantly associated with an abnormal electrocardiogram
Parameters NR
Original Genome Build GRCh37
Number of Variants 6
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000241
Citation (link to publication) Wang M et al. Sci Rep (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
1,006 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST012208
Europe PMC: 33633301
1,006 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002983 PSS001451|
East Asian Ancestry|
100 individuals
PGP000241 |
Wang M et al. Sci Rep (2021)
Reported Trait: Abnormal electrocardiogram AUROC: 0.72 Youden's index: 0.4 Age, sex

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001451 100 individuals East Asian
(Han Chinese)