Polygenic Score (PGS) ID: PGS000926

Predicted Trait
Reported Trait Daytime dozing / sleeping (narcolepsy)
Mapped Trait(s) narcolepsy (MONDO_0021107)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/QT_FC1001220
Released in PGS Catalog: Oct. 21, 2021
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Score Details

Score Construction
PGS Name GBE_QT_FC1001220
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 4,194
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
268,858 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 268,858 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007457 PSS007536|
African Ancestry|
6,254 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — R²: 0.02468 [0.01723, 0.03213]
Incremental R2 (full-covars): -0.00089
PGS R2 (no covariates): 0.00034 [-0.00056, 0.00125]		 age, sex, UKB array type, Genotype PCs —
PPM007458 PSS007537|
East Asian Ancestry|
1,629 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — Incremental R2 (full-covars): 0.00183
R²: 0.03667 [0.01919, 0.05415]
PGS R2 (no covariates): 0.00244 [-0.00223, 0.0071]		 age, sex, UKB array type, Genotype PCs —
PPM007459 PSS007538|
European Ancestry|
24,713 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — R²: 0.02067 [0.01717, 0.02417]
Incremental R2 (full-covars): 0.00439
PGS R2 (no covariates): 0.00422 [0.00261, 0.00583]		 age, sex, UKB array type, Genotype PCs —
PPM007460 PSS007539|
South Asian Ancestry|
7,410 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — R²: 0.0158 [0.01032, 0.02128]
Incremental R2 (full-covars): 0.00236
PGS R2 (no covariates): 0.00251 [0.0003, 0.00473]		 age, sex, UKB array type, Genotype PCs —
PPM007461 PSS007540|
European Ancestry|
67,196 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — R²: 0.02284 [0.02061, 0.02507]
Incremental R2 (full-covars): 0.00532
PGS R2 (no covariates): 0.00542 [0.00431, 0.00652]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007536 — — 6,254 individuals — African unspecified — UKB —
PSS007537 — — 1,629 individuals — East Asian — UKB —
PSS007538 — — 24,713 individuals — European non-white British ancestry UKB —
PSS007539 — — 7,410 individuals — South Asian — UKB —
PSS007540 — — 67,196 individuals — European white British ancestry UKB Testing cohort (heldout set)