Polygenic Score (PGS) ID: PGS001054

Predicted Trait
Reported Trait Snoring
Mapped Trait(s) snoring measurement (EFO_0008341)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN1210
Released in PGS Catalog: Oct. 21, 2021
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_BIN1210
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 7,407
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. medRxiv (2021) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
252,696 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
[
  • 97,690 cases
  • , 155,006 controls
]
European white British ancestry UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008028 PSS003632|
African Ancestry|
5,724 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Snoring AUROC: 0.56752 [0.55195, 0.58308] : 0.01836
Incremental AUROC (full-covars): 0.00418
PGS R2 (no covariates): 0.00323
PGS AUROC (no covariates): 0.52957 [0.51394, 0.54521]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008029 PSS003633|
East Asian Ancestry|
1,487 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Snoring AUROC: 0.67171 [0.64335, 0.70007] : 0.11762
Incremental AUROC (full-covars): 0.01614
PGS R2 (no covariates): 0.00954
PGS AUROC (no covariates): 0.55576 [0.52576, 0.58577]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008030 PSS003634|
European Ancestry|
22,809 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Snoring AUROC: 0.6348 [0.62735, 0.64225] : 0.06823
Incremental AUROC (full-covars): 0.01869
PGS R2 (no covariates): 0.01264
PGS AUROC (no covariates): 0.55683 [0.5491, 0.56456]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008031 PSS003635|
South Asian Ancestry|
6,976 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Snoring AUROC: 0.60905 [0.59574, 0.62235] : 0.04773
Incremental AUROC (full-covars): 0.0076
PGS R2 (no covariates): 0.00635
PGS AUROC (no covariates): 0.54076 [0.52704, 0.55447]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008032 PSS003636|
European Ancestry|
63,239 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Snoring AUROC: 0.6302 [0.62577, 0.63463] : 0.06538
Incremental AUROC (full-covars): 0.01667
PGS R2 (no covariates): 0.01001
PGS AUROC (no covariates): 0.54987 [0.54527, 0.55446]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003632
[
  • 2,011 cases
  • , 3,713 controls
]
African unspecified UKB
PSS003633
[
  • 557 cases
  • , 930 controls
]
East Asian UKB
PSS003634
[
  • 8,244 cases
  • , 14,565 controls
]
European non-white British ancestry UKB
PSS003635
[
  • 2,920 cases
  • , 4,056 controls
]
South Asian UKB
PSS003636
[
  • 24,281 cases
  • , 38,958 controls
]
European white British ancestry UKB Testing cohort (heldout set)