Polygenic Score (PGS) ID: PGS001102

Predicted Trait
Reported Trait Body fat percentage (left arm)
Mapped Trait(s) body fat percentage (EFO_0007800)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI23123
Released in PGS Catalog: Oct. 21, 2021
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI23123
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 25,266
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
265,084 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
265,084 individuals European UKB white British ancestry

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008249 PSS005141|
African Ancestry|
6,301 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Arm fat % (L) Incremental R2 (full-covars): -3e-05
: 0.60446 [0.58951, 0.61941]
PGS R2 (no covariates): 0.00397 [0.00092, 0.00702]
age, sex, UKB array type, Genotype PCs
PPM008250 PSS005142|
East Asian Ancestry|
1,678 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Arm fat % (L) : 0.47666 [0.44242, 0.5109]
Incremental R2 (full-covars): 0.00986
PGS R2 (no covariates): 0.03708 [0.01951, 0.05465]
age, sex, UKB array type, Genotype PCs
PPM008251 PSS005143|
European Ancestry|
24,458 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Arm fat % (L) : 0.46034 [0.45125, 0.46943]
Incremental R2 (full-covars): 0.05013
PGS R2 (no covariates): 0.04532 [0.04027, 0.05037]
age, sex, UKB array type, Genotype PCs
PPM008252 PSS005144|
South Asian Ancestry|
7,648 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Arm fat % (L) : 0.60959 [0.59609, 0.62308]
Incremental R2 (full-covars): 0.02061
PGS R2 (no covariates): 0.02621 [0.01923, 0.03318]
age, sex, UKB array type, Genotype PCs
PPM008253 PSS005145|
European Ancestry|
66,244 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Arm fat % (L) : 0.51263 [0.50736, 0.5179]
Incremental R2 (full-covars): 0.04899
PGS R2 (no covariates): 0.04847 [0.04531, 0.05163]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005141 6,301 individuals African unspecified UKB
PSS005142 1,678 individuals East Asian UKB
PSS005143 24,458 individuals European non-white British ancestry UKB
PSS005144 7,648 individuals South Asian UKB
PSS005145 66,244 individuals European white British ancestry UKB Testing cohort (heldout set)