Polygenic Score (PGS) ID: PGS001112

Predicted Trait
Reported Trait Aspirin
Mapped Trait(s) aspirin use measurement (EFO_0007013)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN_FC1006154
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_BIN_FC1006154
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 499
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
267,242 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 39,198 cases
  • , 228,044 controls
]
 European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008298 PSS003785|
African Ancestry|
6,221 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Aspirin — AUROC: 0.69049 [0.67139, 0.70958] R²: 0.10001
Incremental AUROC (full-covars): -0.00083
PGS R2 (no covariates): 2e-05
PGS AUROC (no covariates): 0.49929 [0.47866, 0.51992]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008299 PSS003786|
East Asian Ancestry|
1,584 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Aspirin — AUROC: 0.70571 [0.6571, 0.75432] R²: 0.08987
Incremental AUROC (full-covars): 0.0038
PGS R2 (no covariates): 0.00669
PGS AUROC (no covariates): 0.56392 [0.50988, 0.61796]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008300 PSS003787|
European Ancestry|
24,612 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Aspirin — AUROC: 0.68372 [0.67417, 0.69326] R²: 0.09126
Incremental AUROC (full-covars): 0.00057
PGS R2 (no covariates): 0.00095
PGS AUROC (no covariates): 0.51838 [0.50799, 0.52876]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008301 PSS003788|
South Asian Ancestry|
7,364 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Aspirin — AUROC: 0.73243 [0.71849, 0.74637] R²: 0.16473
Incremental AUROC (full-covars): 0.00284
PGS R2 (no covariates): 0.00525
PGS AUROC (no covariates): 0.5396 [0.52315, 0.55606]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008302 PSS003789|
European Ancestry|
66,854 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Aspirin — AUROC: 0.70264 [0.69719, 0.70809] R²: 0.11105
Incremental AUROC (full-covars): 0.00128
PGS R2 (no covariates): 0.00131
PGS AUROC (no covariates): 0.52069 [0.5145, 0.52688]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003785 — —
[
  • 879 cases
  • , 5,342 controls
]
 — African unspecified — UKB —
PSS003786 — —
[
  • 120 cases
  • , 1,464 controls
]
 — East Asian — UKB —
PSS003787 — —
[
  • 3,508 cases
  • , 21,104 controls
]
 — European non-white British ancestry UKB —
PSS003788 — —
[
  • 1,478 cases
  • , 5,886 controls
]
 — South Asian — UKB —
PSS003789 — —
[
  • 9,771 cases
  • , 57,083 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)