Polygenic Score (PGS) ID: PGS001114

Predicted Trait
Reported Trait Ibuprofen use, self-reported
Mapped Trait(s)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN_FC8006154
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_BIN_FC8006154
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 419
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
191,269 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 41,746 cases
  • , 149,523 controls
]
 European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008308 PSS004019|
African Ancestry|
4,198 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen use self-reported — AUROC: 0.58623 [0.56747, 0.60499] R²: 0.02659
Incremental AUROC (full-covars): 0.00105
PGS R2 (no covariates): 0.00105
PGS AUROC (no covariates): 0.51676 [0.49751, 0.53601]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008309 PSS004020|
East Asian Ancestry|
1,283 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen use self-reported — AUROC: 0.63391 [0.58944, 0.67838] R²: 0.07333
Incremental AUROC (full-covars): 0.00219
PGS R2 (no covariates): 0.00605
PGS AUROC (no covariates): 0.55222 [0.50424, 0.60019]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008310 PSS004021|
European Ancestry|
18,055 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen use self-reported — AUROC: 0.59904 [0.58905, 0.60903] R²: 0.03286
Incremental AUROC (full-covars): 0.00267
PGS R2 (no covariates): 0.00221
PGS AUROC (no covariates): 0.52523 [0.51521, 0.53524]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008311 PSS004022|
South Asian Ancestry|
4,705 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen use self-reported — AUROC: 0.61281 [0.59188, 0.63374] R²: 0.036
Incremental AUROC (full-covars): -0.00199
PGS R2 (no covariates): 3e-05
PGS AUROC (no covariates): 0.49833 [0.47621, 0.52045]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008312 PSS004023|
European Ancestry|
47,828 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen use self-reported — AUROC: 0.59831 [0.59215, 0.60447] R²: 0.03148
Incremental AUROC (full-covars): 0.00304
PGS R2 (no covariates): 0.00188
PGS AUROC (no covariates): 0.52406 [0.51781, 0.5303]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004019 — —
[
  • 1,214 cases
  • , 2,984 controls
]
 — African unspecified — UKB —
PSS004020 — —
[
  • 166 cases
  • , 1,117 controls
]
 — East Asian — UKB —
PSS004021 — —
[
  • 4,084 cases
  • , 13,971 controls
]
 — European non-white British ancestry UKB —
PSS004022 — —
[
  • 811 cases
  • , 3,894 controls
]
 — South Asian — UKB —
PSS004023 — —
[
  • 10,489 cases
  • , 37,339 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)