Polygenic Score (PGS) ID: PGS001116

Predicted Trait
Reported Trait Ibuprofen use
Mapped Trait(s) NSAID use measurement (EFO_0007012)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN_FC2006154
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_BIN_FC2006154
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 174
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
267,242 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 41,746 cases
  • , 225,496 controls
]
 European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008318 PSS003859|
African Ancestry|
6,221 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen (e.g. Nurofen) — AUROC: 0.59205 [0.57467, 0.60944] R²: 0.02759
Incremental AUROC (full-covars): -0.00015
PGS R2 (no covariates): 0.00046
PGS AUROC (no covariates): 0.50964 [0.4914, 0.52789]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008319 PSS003860|
East Asian Ancestry|
1,584 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen (e.g. Nurofen) — AUROC: 0.61277 [0.5683, 0.65725] R²: 0.04562
Incremental AUROC (full-covars): 0.00152
PGS R2 (no covariates): 0.00555
PGS AUROC (no covariates): 0.54922 [0.50243, 0.59601]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008320 PSS003861|
European Ancestry|
24,612 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen (e.g. Nurofen) — AUROC: 0.61988 [0.61042, 0.62934] R²: 0.04208
Incremental AUROC (full-covars): 0.00089
PGS R2 (no covariates): 0.001
PGS AUROC (no covariates): 0.51881 [0.50908, 0.52853]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008321 PSS003862|
South Asian Ancestry|
7,364 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen (e.g. Nurofen) — AUROC: 0.62217 [0.6023, 0.64205] R²: 0.03601
Incremental AUROC (full-covars): -0.00195
PGS R2 (no covariates): 0.00051
PGS AUROC (no covariates): 0.48821 [0.46651, 0.50992]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008322 PSS003863|
European Ancestry|
66,854 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ibuprofen (e.g. Nurofen) — AUROC: 0.61851 [0.6127, 0.62433] R²: 0.03928
Incremental AUROC (full-covars): 0.00101
PGS R2 (no covariates): 0.00076
PGS AUROC (no covariates): 0.51542 [0.50941, 0.52143]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003859 — —
[
  • 1,214 cases
  • , 5,007 controls
]
 — African unspecified — UKB —
PSS003860 — —
[
  • 166 cases
  • , 1,418 controls
]
 — East Asian — UKB —
PSS003861 — —
[
  • 4,084 cases
  • , 20,528 controls
]
 — European non-white British ancestry UKB —
PSS003862 — —
[
  • 811 cases
  • , 6,553 controls
]
 — South Asian — UKB —
PSS003863 — —
[
  • 10,489 cases
  • , 56,365 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)