Polygenic Score (PGS) ID: PGS001119

Predicted Trait
Reported Trait Left hand grip strength
Mapped Trait(s) grip strength measurement (EFO_0006941)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI46
Released in PGS Catalog: Oct. 21, 2021
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI46
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 13,767
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
268,691 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 268,691 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008333 PSS007346|
African Ancestry|
6,406 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hand grip strength (L) — — R²: 0.46137 [0.44358, 0.47915]
Incremental R2 (full-covars): -0.00082
PGS R2 (no covariates): 0.00155 [-0.00036, 0.00346]		 age, sex, UKB array type, Genotype PCs —
PPM008334 PSS007347|
East Asian Ancestry|
1,696 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hand grip strength (L) — — R²: 0.51785 [0.48497, 0.55073]
Incremental R2 (full-covars): 0.00522
PGS R2 (no covariates): 0.01076 [0.00104, 0.02048]		 age, sex, UKB array type, Genotype PCs —
PPM008335 PSS007348|
European Ancestry|
24,787 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hand grip strength (L) — — R²: 0.54413 [0.53578, 0.55248]
Incremental R2 (full-covars): 0.01167
PGS R2 (no covariates): 0.01075 [0.0082, 0.01329]		 age, sex, UKB array type, Genotype PCs —
PPM008336 PSS007349|
South Asian Ancestry|
7,727 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hand grip strength (L) — — R²: 0.48797 [0.47214, 0.50381]
Incremental R2 (full-covars): 0.00538
PGS R2 (no covariates): 0.00871 [0.00462, 0.01281]		 age, sex, UKB array type, Genotype PCs —
PPM008337 PSS007350|
European Ancestry|
67,154 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hand grip strength (L) — — R²: 0.57766 [0.57281, 0.5825]
Incremental R2 (full-covars): 0.01506
PGS R2 (no covariates): 0.01441 [0.01262, 0.0162]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007346 — — 6,406 individuals — African unspecified — UKB —
PSS007347 — — 1,696 individuals — East Asian — UKB —
PSS007348 — — 24,787 individuals — European non-white British ancestry UKB —
PSS007349 — — 7,727 individuals — South Asian — UKB —
PSS007350 — — 67,154 individuals — European white British ancestry UKB Testing cohort (heldout set)