Polygenic Score (PGS) ID: PGS001199

Predicted Trait
Reported Trait Lymphocyte count
Mapped Trait(s) lymphocyte count (EFO_0004587)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI30120
Released in PGS Catalog: Oct. 21, 2021
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI30120
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 4,212
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
261,890 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 261,890 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008616 PSS006968|
European Ancestry|
24,129 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Lymphocyte count — — R²: 0.04047 [0.03568, 0.04526]
Incremental R2 (full-covars): 0.03437
PGS R2 (no covariates): 0.03502 [0.03053, 0.0395]		 age, sex, UKB array type, Genotype PCs —
PPM008614 PSS006966|
African Ancestry|
6,120 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Lymphocyte count — — R²: 0.01509 [0.00921, 0.02097]
Incremental R2 (full-covars): 0.0048
PGS R2 (no covariates): 0.00655 [0.00264, 0.01046]		 age, sex, UKB array type, Genotype PCs —
PPM008615 PSS006967|
East Asian Ancestry|
1,654 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Lymphocyte count — — R²: 0.07751 [0.05317, 0.10185]
Incremental R2 (full-covars): 0.02783
PGS R2 (no covariates): 0.0308 [0.01468, 0.04692]		 age, sex, UKB array type, Genotype PCs —
PPM008617 PSS006969|
South Asian Ancestry|
7,491 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Lymphocyte count — — R²: 0.04041 [0.03187, 0.04896]
Incremental R2 (full-covars): 0.02891
PGS R2 (no covariates): 0.02928 [0.02192, 0.03663]		 age, sex, UKB array type, Genotype PCs —
PPM008618 PSS006970|
European Ancestry|
65,520 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Lymphocyte count — — R²: 0.02566 [0.0233, 0.02801]
Incremental R2 (full-covars): 0.02051
PGS R2 (no covariates): 0.02072 [0.01859, 0.02285]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS006966 — — 6,120 individuals — African unspecified — UKB —
PSS006967 — — 1,654 individuals — East Asian — UKB —
PSS006968 — — 24,129 individuals — European non-white British ancestry UKB —
PSS006969 — — 7,491 individuals — South Asian — UKB —
PSS006970 — — 65,520 individuals — European white British ancestry UKB Testing cohort (heldout set)