Polygenic Score (PGS) ID: PGS001232

Predicted Trait
Reported Trait Fluid intelligence score
Mapped Trait(s) intelligence (EFO_0004337)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI20016
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI20016
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 10,055
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
109,369 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 109,369 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008669 PSS004891|
African Ancestry|
3,281 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Fluid intelligence score — — R²: 0.01453 [0.00875, 0.0203]
Incremental R2 (full-covars): -0.01682
PGS R2 (no covariates): 0.00026 [-0.00053, 0.00105]		 age, sex, UKB array type, Genotype PCs —
PPM008670 PSS004892|
East Asian Ancestry|
716 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Fluid intelligence score — — R²: 0.06194 [0.03982, 0.08407]
Incremental R2 (full-covars): -0.023
PGS R2 (no covariates): 0.00235 [-0.00223, 0.00694]		 age, sex, UKB array type, Genotype PCs —
PPM008671 PSS004893|
European Ancestry|
10,867 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Fluid intelligence score — — R²: 0.12663 [0.11891, 0.13435]
Incremental R2 (full-covars): 0.02765
PGS R2 (no covariates): 0.03358 [0.02918, 0.03797]		 age, sex, UKB array type, Genotype PCs —
PPM008672 PSS004894|
South Asian Ancestry|
3,933 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Fluid intelligence score — — R²: 0.04498 [0.03601, 0.05394]
Incremental R2 (full-covars): 0.01256
PGS R2 (no covariates): 0.01775 [0.01195, 0.02354]		 age, sex, UKB array type, Genotype PCs —
PPM008673 PSS004895|
European Ancestry|
27,171 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Fluid intelligence score — — R²: 0.06613 [0.0625, 0.06975]
Incremental R2 (full-covars): 0.0502
PGS R2 (no covariates): 0.05073 [0.0475, 0.05395]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004892 — — 716 individuals — East Asian — UKB —
PSS004893 — — 10,867 individuals — European non-white British ancestry UKB —
PSS004894 — — 3,933 individuals — South Asian — UKB —
PSS004895 — — 27,171 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS004891 — — 3,281 individuals — African unspecified — UKB —