Polygenic Score (PGS) ID: PGS001233

Predicted Trait
Reported Trait Heart rate (AR)
Mapped Trait(s) heart rate (EFO_0004326)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI102
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI102
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 14,455
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. medRxiv (2021) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
255,692 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
255,692 individuals European white British ancestry UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008674 PSS004781|
African Ancestry|
6,409 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Pulse rate (AR) : 0.02255 [0.01542, 0.02969]
Incremental R2 (full-covars): 0.0174
PGS R2 (no covariates): 0.01806 [0.01165, 0.02447]
age, sex, UKB array type, Genotype PCs
PPM008675 PSS004782|
East Asian Ancestry|
1,634 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Pulse rate (AR) : 0.06312 [0.04082, 0.08543]
Incremental R2 (full-covars): 0.04857
PGS R2 (no covariates): 0.05506 [0.03405, 0.07607]
age, sex, UKB array type, Genotype PCs
PPM008676 PSS004783|
European Ancestry|
23,727 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Pulse rate (AR) : 0.06698 [0.06098, 0.07297]
Incremental R2 (full-covars): 0.06128
PGS R2 (no covariates): 0.06178 [0.05599, 0.06757]
age, sex, UKB array type, Genotype PCs
PPM008677 PSS004784|
South Asian Ancestry|
7,640 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Pulse rate (AR) : 0.05587 [0.04599, 0.06575]
Incremental R2 (full-covars): 0.04337
PGS R2 (no covariates): 0.04305 [0.03426, 0.05184]
age, sex, UKB array type, Genotype PCs
PPM008678 PSS004785|
European Ancestry|
63,825 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Pulse rate (AR) : 0.07415 [0.07034, 0.07795]
Incremental R2 (full-covars): 0.06338
PGS R2 (no covariates): 0.06346 [0.0599, 0.06702]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004781 6,409 individuals African unspecified UKB
PSS004782 1,634 individuals East Asian UKB
PSS004783 23,727 individuals European non-white British ancestry UKB
PSS004784 7,640 individuals South Asian UKB
PSS004785 63,825 individuals European white British ancestry UKB Testing cohort (heldout set)