Polygenic Score (PGS) ID: PGS001355

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Nov. 4, 2021
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Score Details

Score Construction
PGS Name CAD_AnnoPred_PRS
Development Method
Name AnnoPred
Parameters Tier2, pT, p=0.003
Original Genome Build hg19
Number of Variants 2,994,055
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000252
Citation (link to publication) Ye Y et al. Circ Genom Precis Med (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
184,305 individuals (100%)
Score Development/Training
European: 100%
92,928 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 10.1038/ng.3396
  • 60,801 cases
  • , 123,504 controls
European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
  • 4,746 cases
  • , 88,182 controls
European UKB Mean = 56.81 years

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005187 PSS003605|
European Ancestry|
176,238 individuals
PGP000252 |
Ye Y et al. Circ Genom Precis Med (2021)
Reported Trait: Coronary artery disease AUROC: 0.6425 Age, sex, PCs(1-10)
PPM019106 PSS011183|
European Ancestry|
166,714 individuals
PGP000506 |
Jowell A et al. Eur J Prev Cardiol (2023)
Reported Trait: Family history of heart disease OR: 1.17 [1.16, 1.19]

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 72,052 cases
  • , 94,662 controls
44.3 % Male samples
Mean = 56.2 years
Sd = 8.05 years
  • 3,467 cases
  • , 172,771 controls
Mean = 56.81 years European UKB