Polygenic Score (PGS) ID: PGS001356

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: Nov. 4, 2021
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Score Details

Score Construction
PGS Name AF_AnnoPred_PRS
Development Method
Name AnnoPred
Parameters Tier3, h2, p=0.01
Variants
Original Genome Build hg19
Number of Variants 2,996,793
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000252
Citation (link to publication) Ye Y et al. Circ Genom Precis Med (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
133,073 individuals (100%)
Score Development/Training
European: 100%
92,928 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 10.1038/ng.3396
[
  • 17,931 cases
  • , 115,142 controls
]
 European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 3,606 cases
  • , 89,322 controls
]
 European UKB — Mean = 56.81 years — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005188 PSS003604|
European Ancestry|
178,651 individuals
 PGP000252 |
Ye Y et al. Circ Genom Precis Med (2021)
 Reported Trait: Atrial fibrillation — AUROC: 0.6321 — Age, sex, PCs(1-10) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003604 — —
[
  • 4,025 cases
  • , 174,626 controls
]
 Mean = 56.81 years European — UKB —