Polygenic Score (PGS) ID: PGS001384

Predicted Trait
Reported Trait Degree bothered by feeling tired all the time in the last 3 months
Mapped Trait(s) health-related quality of life measurement (EFO_0011014)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI21060
Released in PGS Catalog: Nov. 25, 2021
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI21060
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,526
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
97,905 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 97,905 individuals European UKB — — — white British ancestry Training + validation cohort (train_val)

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005285 PSS004946|
African Ancestry|
1,001 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Degree bothered by feeling tired all the time in the last 3 months — — R²: 0.09569 [0.08209, 0.10929]
Incremental R2 (full-covars): 0.0007
PGS R2 (no covariates): 0.00137 [-0.00043, 0.00317]		 age, sex, UKB array type, Genotype PCs —
PPM005286 PSS004947|
East Asian Ancestry|
396 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Degree bothered by feeling tired all the time in the last 3 months — — R²: 0.01263 [0.00211, 0.02314]
Incremental R2 (full-covars): -0.00541
PGS R2 (no covariates): 0.00111 [-0.00204, 0.00426]		 age, sex, UKB array type, Genotype PCs —
PPM005287 PSS004948|
European Ancestry|
9,142 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Degree bothered by feeling tired all the time in the last 3 months — — R²: 0.02527 [0.02142, 0.02912]
Incremental R2 (full-covars): 0.00181
PGS R2 (no covariates): 0.00196 [0.00086, 0.00306]		 age, sex, UKB array type, Genotype PCs —
PPM005288 PSS004949|
South Asian Ancestry|
1,195 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Degree bothered by feeling tired all the time in the last 3 months — — R²: 0.06915 [0.05831, 0.07999]
Incremental R2 (full-covars): -0.00114
PGS R2 (no covariates): 0.00011 [-0.00036, 0.00058]		 age, sex, UKB array type, Genotype PCs —
PPM005289 PSS004950|
European Ancestry|
24,446 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Degree bothered by feeling tired all the time in the last 3 months — — R²: 0.02337 [0.02111, 0.02562]
Incremental R2 (full-covars): 0.00111
PGS R2 (no covariates): 0.00164 [0.00103, 0.00225]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004946 — — 1,001 individuals — African unspecified — UKB —
PSS004947 — — 396 individuals — East Asian — UKB —
PSS004948 — — 9,142 individuals — European non-white British ancestry UKB —
PSS004949 — — 1,195 individuals — South Asian — UKB —
PSS004950 — — 24,446 individuals — European white British ancestry UKB Testing cohort (heldout set)