| Predicted Trait | |
| Reported Trait | Volume of grey matter in Temporal Fusiform Cortex, anterior division (L) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25854 |
| Score Construction | |
| PGS Name | GBE_INI25854 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 264 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006775 | PSS006616| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, anterior division (L) | — | — | R²: 0.18745 [0.17035, 0.20455] Incremental R2 (full-covars): 0.01004 PGS R2 (no covariates): 0.00732 [0.00319, 0.01145] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006776 | PSS006617| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, anterior division (L) | — | — | R²: 0.18256 [0.14946, 0.21566] Incremental R2 (full-covars): -0.01287 PGS R2 (no covariates): 0.00539 [-0.00153, 0.01232] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006777 | PSS006618| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, anterior division (L) | — | — | R²: 0.17172 [0.16319, 0.18024] Incremental R2 (full-covars): 0.00284 PGS R2 (no covariates): 0.00387 [0.00233, 0.00541] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006778 | PSS006619| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, anterior division (L) | — | — | R²: 0.19672 [0.18095, 0.2125] Incremental R2 (full-covars): -2e-05 PGS R2 (no covariates): 0.0003 [-0.00047, 0.00106] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006779 | PSS006620| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, anterior division (L) | — | — | R²: 0.16323 [0.15813, 0.16834] Incremental R2 (full-covars): 0.00507 PGS R2 (no covariates): 0.00554 [0.00442, 0.00665] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006620 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS006616 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006617 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006618 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006619 | — | — | 329 individuals | — | South Asian | — | UKB | — |